Cargando…
The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19
The increased plasma levels of von Willebrand factor (VWF) in patients with COVID-19 was reported in many studies, and its correlation with disease severity and mortality suggest its important role in the pathogenesis of thrombosis in COVID-19. We performed histological and immunohistochemical studi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874644/ https://www.ncbi.nlm.nih.gov/pubmed/35215805 http://dx.doi.org/10.3390/v14020211 |
_version_ | 1784657738029072384 |
---|---|
author | Babkina, Anastasiya S. Ostrova, Irina V. Yadgarov, Mikhail Ya Kuzovlev, Artem N. Grechko, Andrey V. Volkov, Alexey V. Golubev, Arkady M. |
author_facet | Babkina, Anastasiya S. Ostrova, Irina V. Yadgarov, Mikhail Ya Kuzovlev, Artem N. Grechko, Andrey V. Volkov, Alexey V. Golubev, Arkady M. |
author_sort | Babkina, Anastasiya S. |
collection | PubMed |
description | The increased plasma levels of von Willebrand factor (VWF) in patients with COVID-19 was reported in many studies, and its correlation with disease severity and mortality suggest its important role in the pathogenesis of thrombosis in COVID-19. We performed histological and immunohistochemical studies of the lungs of 29 patients who died from COVID-19. We found a significant increase in the intensity of immunohistochemical reaction for VWF in the pulmonary vascular endothelium when the disease duration was more than 10 days. In the patients who had thrombotic complications, the VWF immunostaining in the pulmonary vascular endothelium was significantly more intense than in nonsurvivors without thrombotic complications. Duration of disease and thrombotic complications were found to be independent predictors of increased VWF immunostaining in the endothelium of pulmonary vessels. We also revealed that bacterial pneumonia was associated with increased VWF staining intensity in pulmonary arterial, arteriolar, and venular endothelium, while lung ventilation was an independent predictor of increased VWF immunostaining in arterial endothelium. The results of the study demonstrated an important role of endothelial VWF in the pathogenesis of thrombus formation in COVID-19. |
format | Online Article Text |
id | pubmed-8874644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88746442022-02-26 The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19 Babkina, Anastasiya S. Ostrova, Irina V. Yadgarov, Mikhail Ya Kuzovlev, Artem N. Grechko, Andrey V. Volkov, Alexey V. Golubev, Arkady M. Viruses Article The increased plasma levels of von Willebrand factor (VWF) in patients with COVID-19 was reported in many studies, and its correlation with disease severity and mortality suggest its important role in the pathogenesis of thrombosis in COVID-19. We performed histological and immunohistochemical studies of the lungs of 29 patients who died from COVID-19. We found a significant increase in the intensity of immunohistochemical reaction for VWF in the pulmonary vascular endothelium when the disease duration was more than 10 days. In the patients who had thrombotic complications, the VWF immunostaining in the pulmonary vascular endothelium was significantly more intense than in nonsurvivors without thrombotic complications. Duration of disease and thrombotic complications were found to be independent predictors of increased VWF immunostaining in the endothelium of pulmonary vessels. We also revealed that bacterial pneumonia was associated with increased VWF staining intensity in pulmonary arterial, arteriolar, and venular endothelium, while lung ventilation was an independent predictor of increased VWF immunostaining in arterial endothelium. The results of the study demonstrated an important role of endothelial VWF in the pathogenesis of thrombus formation in COVID-19. MDPI 2022-01-21 /pmc/articles/PMC8874644/ /pubmed/35215805 http://dx.doi.org/10.3390/v14020211 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Babkina, Anastasiya S. Ostrova, Irina V. Yadgarov, Mikhail Ya Kuzovlev, Artem N. Grechko, Andrey V. Volkov, Alexey V. Golubev, Arkady M. The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19 |
title | The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19 |
title_full | The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19 |
title_fullStr | The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19 |
title_full_unstemmed | The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19 |
title_short | The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19 |
title_sort | role of von willebrand factor in the pathogenesis of pulmonary vascular thrombosis in covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874644/ https://www.ncbi.nlm.nih.gov/pubmed/35215805 http://dx.doi.org/10.3390/v14020211 |
work_keys_str_mv | AT babkinaanastasiyas theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT ostrovairinav theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT yadgarovmikhailya theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT kuzovlevartemn theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT grechkoandreyv theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT volkovalexeyv theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT golubevarkadym theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT babkinaanastasiyas roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT ostrovairinav roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT yadgarovmikhailya roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT kuzovlevartemn roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT grechkoandreyv roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT volkovalexeyv roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 AT golubevarkadym roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19 |