Cargando…

The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19

The increased plasma levels of von Willebrand factor (VWF) in patients with COVID-19 was reported in many studies, and its correlation with disease severity and mortality suggest its important role in the pathogenesis of thrombosis in COVID-19. We performed histological and immunohistochemical studi...

Descripción completa

Detalles Bibliográficos
Autores principales: Babkina, Anastasiya S., Ostrova, Irina V., Yadgarov, Mikhail Ya, Kuzovlev, Artem N., Grechko, Andrey V., Volkov, Alexey V., Golubev, Arkady M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874644/
https://www.ncbi.nlm.nih.gov/pubmed/35215805
http://dx.doi.org/10.3390/v14020211
_version_ 1784657738029072384
author Babkina, Anastasiya S.
Ostrova, Irina V.
Yadgarov, Mikhail Ya
Kuzovlev, Artem N.
Grechko, Andrey V.
Volkov, Alexey V.
Golubev, Arkady M.
author_facet Babkina, Anastasiya S.
Ostrova, Irina V.
Yadgarov, Mikhail Ya
Kuzovlev, Artem N.
Grechko, Andrey V.
Volkov, Alexey V.
Golubev, Arkady M.
author_sort Babkina, Anastasiya S.
collection PubMed
description The increased plasma levels of von Willebrand factor (VWF) in patients with COVID-19 was reported in many studies, and its correlation with disease severity and mortality suggest its important role in the pathogenesis of thrombosis in COVID-19. We performed histological and immunohistochemical studies of the lungs of 29 patients who died from COVID-19. We found a significant increase in the intensity of immunohistochemical reaction for VWF in the pulmonary vascular endothelium when the disease duration was more than 10 days. In the patients who had thrombotic complications, the VWF immunostaining in the pulmonary vascular endothelium was significantly more intense than in nonsurvivors without thrombotic complications. Duration of disease and thrombotic complications were found to be independent predictors of increased VWF immunostaining in the endothelium of pulmonary vessels. We also revealed that bacterial pneumonia was associated with increased VWF staining intensity in pulmonary arterial, arteriolar, and venular endothelium, while lung ventilation was an independent predictor of increased VWF immunostaining in arterial endothelium. The results of the study demonstrated an important role of endothelial VWF in the pathogenesis of thrombus formation in COVID-19.
format Online
Article
Text
id pubmed-8874644
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88746442022-02-26 The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19 Babkina, Anastasiya S. Ostrova, Irina V. Yadgarov, Mikhail Ya Kuzovlev, Artem N. Grechko, Andrey V. Volkov, Alexey V. Golubev, Arkady M. Viruses Article The increased plasma levels of von Willebrand factor (VWF) in patients with COVID-19 was reported in many studies, and its correlation with disease severity and mortality suggest its important role in the pathogenesis of thrombosis in COVID-19. We performed histological and immunohistochemical studies of the lungs of 29 patients who died from COVID-19. We found a significant increase in the intensity of immunohistochemical reaction for VWF in the pulmonary vascular endothelium when the disease duration was more than 10 days. In the patients who had thrombotic complications, the VWF immunostaining in the pulmonary vascular endothelium was significantly more intense than in nonsurvivors without thrombotic complications. Duration of disease and thrombotic complications were found to be independent predictors of increased VWF immunostaining in the endothelium of pulmonary vessels. We also revealed that bacterial pneumonia was associated with increased VWF staining intensity in pulmonary arterial, arteriolar, and venular endothelium, while lung ventilation was an independent predictor of increased VWF immunostaining in arterial endothelium. The results of the study demonstrated an important role of endothelial VWF in the pathogenesis of thrombus formation in COVID-19. MDPI 2022-01-21 /pmc/articles/PMC8874644/ /pubmed/35215805 http://dx.doi.org/10.3390/v14020211 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Babkina, Anastasiya S.
Ostrova, Irina V.
Yadgarov, Mikhail Ya
Kuzovlev, Artem N.
Grechko, Andrey V.
Volkov, Alexey V.
Golubev, Arkady M.
The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19
title The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19
title_full The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19
title_fullStr The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19
title_full_unstemmed The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19
title_short The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19
title_sort role of von willebrand factor in the pathogenesis of pulmonary vascular thrombosis in covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874644/
https://www.ncbi.nlm.nih.gov/pubmed/35215805
http://dx.doi.org/10.3390/v14020211
work_keys_str_mv AT babkinaanastasiyas theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT ostrovairinav theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT yadgarovmikhailya theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT kuzovlevartemn theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT grechkoandreyv theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT volkovalexeyv theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT golubevarkadym theroleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT babkinaanastasiyas roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT ostrovairinav roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT yadgarovmikhailya roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT kuzovlevartemn roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT grechkoandreyv roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT volkovalexeyv roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19
AT golubevarkadym roleofvonwillebrandfactorinthepathogenesisofpulmonaryvascularthrombosisincovid19