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Bacterial Ribosome Rescue Systems
To maintain proteostasis, the cell employs multiple ribosome rescue systems to relieve the stalled ribosome on problematic mRNA. One example of problematic mRNA is non-stop mRNA that lacks an in-frame stop codon produced by endonucleolytic cleavage or transcription error. In Escherichia coli, there...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874680/ https://www.ncbi.nlm.nih.gov/pubmed/35208827 http://dx.doi.org/10.3390/microorganisms10020372 |
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author | Kurita, Daisuke Himeno, Hyouta |
author_facet | Kurita, Daisuke Himeno, Hyouta |
author_sort | Kurita, Daisuke |
collection | PubMed |
description | To maintain proteostasis, the cell employs multiple ribosome rescue systems to relieve the stalled ribosome on problematic mRNA. One example of problematic mRNA is non-stop mRNA that lacks an in-frame stop codon produced by endonucleolytic cleavage or transcription error. In Escherichia coli, there are at least three ribosome rescue systems that deal with the ribosome stalled on non-stop mRNA. According to one estimation, 2–4% of translation is the target of ribosome rescue systems even under normal growth conditions. In the present review, we discuss the recent findings of ribosome rescue systems in bacteria. |
format | Online Article Text |
id | pubmed-8874680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88746802022-02-26 Bacterial Ribosome Rescue Systems Kurita, Daisuke Himeno, Hyouta Microorganisms Review To maintain proteostasis, the cell employs multiple ribosome rescue systems to relieve the stalled ribosome on problematic mRNA. One example of problematic mRNA is non-stop mRNA that lacks an in-frame stop codon produced by endonucleolytic cleavage or transcription error. In Escherichia coli, there are at least three ribosome rescue systems that deal with the ribosome stalled on non-stop mRNA. According to one estimation, 2–4% of translation is the target of ribosome rescue systems even under normal growth conditions. In the present review, we discuss the recent findings of ribosome rescue systems in bacteria. MDPI 2022-02-05 /pmc/articles/PMC8874680/ /pubmed/35208827 http://dx.doi.org/10.3390/microorganisms10020372 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kurita, Daisuke Himeno, Hyouta Bacterial Ribosome Rescue Systems |
title | Bacterial Ribosome Rescue Systems |
title_full | Bacterial Ribosome Rescue Systems |
title_fullStr | Bacterial Ribosome Rescue Systems |
title_full_unstemmed | Bacterial Ribosome Rescue Systems |
title_short | Bacterial Ribosome Rescue Systems |
title_sort | bacterial ribosome rescue systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874680/ https://www.ncbi.nlm.nih.gov/pubmed/35208827 http://dx.doi.org/10.3390/microorganisms10020372 |
work_keys_str_mv | AT kuritadaisuke bacterialribosomerescuesystems AT himenohyouta bacterialribosomerescuesystems |