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Evolved DNA Duplex Readers for Strand-Asymmetrically Modified 5-Hydroxymethylcytosine/5-Methylcytosine CpG Dyads

[Image: see text] 5-Methylcytosine (mC) and 5-hydroxymethylcytosine (hmC), the two main epigenetic modifications of mammalian DNA, exist in symmetric and asymmetric combinations in the two strands of CpG dyads. However, revealing such combinations in single DNA duplexes is a significant challenge. H...

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Detalles Bibliográficos
Autores principales:	Buchmuller, Benjamin C., Dröden, Jessica, Singh, Himanshu, Palei, Shubhendu, Drescher, Malte, Linser, Rasmus, Summerer, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874921/ https://www.ncbi.nlm.nih.gov/pubmed/35157801 http://dx.doi.org/10.1021/jacs.1c10678

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