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MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection
Malaria is a severe life-threatening disease caused by the bites of parasite-infected female Anopheles mosquitoes. It remains a significant problem for the most vulnerable children and women. Recent research has helped establish the relationship between microRNAs (miRNAs) and many other diseases. Mi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874942/ https://www.ncbi.nlm.nih.gov/pubmed/35206583 http://dx.doi.org/10.3390/ijerph19042395 |
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author | Kataria, Poonam Surela, Neha Chaudhary, Amrendra Das, Jyoti |
author_facet | Kataria, Poonam Surela, Neha Chaudhary, Amrendra Das, Jyoti |
author_sort | Kataria, Poonam |
collection | PubMed |
description | Malaria is a severe life-threatening disease caused by the bites of parasite-infected female Anopheles mosquitoes. It remains a significant problem for the most vulnerable children and women. Recent research has helped establish the relationship between microRNAs (miRNAs) and many other diseases. MiRNAs are the class of small non-coding RNAs consisting of 18–23 nucleotides in length that are evolutionarily conserved and regulate gene expression at a post-transcriptional level and play a significant role in various molecular mechanisms such as cell survival, cell proliferation, and differentiation. MiRNAs can help detect malaria infection as the malaria parasite could alter the miRNA expression of the host. These alterations can be diagnosed by the molecular diagnostic tool that can indicate disease. We summarize the current understanding of miRNA during malaria infection. miRNAs can also be used as biomarkers, and initial research has unearthed their potential in diagnosing and managing various diseases such as malaria. |
format | Online Article Text |
id | pubmed-8874942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88749422022-02-26 MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection Kataria, Poonam Surela, Neha Chaudhary, Amrendra Das, Jyoti Int J Environ Res Public Health Review Malaria is a severe life-threatening disease caused by the bites of parasite-infected female Anopheles mosquitoes. It remains a significant problem for the most vulnerable children and women. Recent research has helped establish the relationship between microRNAs (miRNAs) and many other diseases. MiRNAs are the class of small non-coding RNAs consisting of 18–23 nucleotides in length that are evolutionarily conserved and regulate gene expression at a post-transcriptional level and play a significant role in various molecular mechanisms such as cell survival, cell proliferation, and differentiation. MiRNAs can help detect malaria infection as the malaria parasite could alter the miRNA expression of the host. These alterations can be diagnosed by the molecular diagnostic tool that can indicate disease. We summarize the current understanding of miRNA during malaria infection. miRNAs can also be used as biomarkers, and initial research has unearthed their potential in diagnosing and managing various diseases such as malaria. MDPI 2022-02-19 /pmc/articles/PMC8874942/ /pubmed/35206583 http://dx.doi.org/10.3390/ijerph19042395 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kataria, Poonam Surela, Neha Chaudhary, Amrendra Das, Jyoti MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection |
title | MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection |
title_full | MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection |
title_fullStr | MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection |
title_full_unstemmed | MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection |
title_short | MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection |
title_sort | mirna: biological regulator in host-parasite interaction during malaria infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874942/ https://www.ncbi.nlm.nih.gov/pubmed/35206583 http://dx.doi.org/10.3390/ijerph19042395 |
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