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Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal Delivery System

Geriatric patients are more likely to suffer from multiple chronic diseases that require using several drugs, which are commonly ingested. However, to enhance geriatric patients’ convenience, the electrospun nanofiber system was previously proven to be a successful alternative for the existing oral...

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Autores principales: Alshaya, Hassa A., Alfahad, Ahmed J., Alsulaihem, Fatemah M., Aodah, Alhassan H., Alshehri, Abdullah A., Almughem, Fahad A., Alfassam, Haya A., Aldossary, Ahmad M., Halwani, Abdulrahman A., Bukhary, Haitham A., Badr, Moutaz Y., Massadeh, Salam, Alaamery, Manal, Tawfik, Essam A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874982/
https://www.ncbi.nlm.nih.gov/pubmed/35214093
http://dx.doi.org/10.3390/pharmaceutics14020358
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author Alshaya, Hassa A.
Alfahad, Ahmed J.
Alsulaihem, Fatemah M.
Aodah, Alhassan H.
Alshehri, Abdullah A.
Almughem, Fahad A.
Alfassam, Haya A.
Aldossary, Ahmad M.
Halwani, Abdulrahman A.
Bukhary, Haitham A.
Badr, Moutaz Y.
Massadeh, Salam
Alaamery, Manal
Tawfik, Essam A.
author_facet Alshaya, Hassa A.
Alfahad, Ahmed J.
Alsulaihem, Fatemah M.
Aodah, Alhassan H.
Alshehri, Abdullah A.
Almughem, Fahad A.
Alfassam, Haya A.
Aldossary, Ahmad M.
Halwani, Abdulrahman A.
Bukhary, Haitham A.
Badr, Moutaz Y.
Massadeh, Salam
Alaamery, Manal
Tawfik, Essam A.
author_sort Alshaya, Hassa A.
collection PubMed
description Geriatric patients are more likely to suffer from multiple chronic diseases that require using several drugs, which are commonly ingested. However, to enhance geriatric patients’ convenience, the electrospun nanofiber system was previously proven to be a successful alternative for the existing oral dosage forms, i.e., tablets and capsules. These nanofibers prepared either as single- or multi-layered fibers could hold at least one active compound in each layer. They might also be fabricated as ultra-disintegrated fibrous films for oral cavity administration, i.e., buccal or sublingual, to improve the bioavailability and intake of the administered drugs. Therefore, in this work, a combination of nifedipine and atorvastatin calcium, which are frequently prescribed for hypertension and hyperlipidemia patients, respectively, was prepared in a coaxial electrospinning system for buccal administration. Scanning electron microscopy image showed the successful preparation of smooth, non-beaded, and non-porous surfaces of the drug-loaded nanofibers with an average fiber diameter of 968 ± 198 nm. In contrast, transmission electron microscopy distinguished the inner and outer layers of those nanofibers. The disintegration of the drug-loaded nanofibers was ≤12 s, allowing the rapid release of nifedipine and atorvastatin calcium to 61% and 47%, respectively, after 10 min, while a complete drug release was achieved after 120 min. In vitro, a drug permeation study using Franz diffusion showed that the permeation of both drugs from the core–shell nanofibers was enhanced significantly (p < 0.05) compared to the drugs in a solution form. In conclusion, the development of drug-loaded nanofibers containing nifedipine and atorvastatin calcium can be a potential buccal delivery system.
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spelling pubmed-88749822022-02-26 Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal Delivery System Alshaya, Hassa A. Alfahad, Ahmed J. Alsulaihem, Fatemah M. Aodah, Alhassan H. Alshehri, Abdullah A. Almughem, Fahad A. Alfassam, Haya A. Aldossary, Ahmad M. Halwani, Abdulrahman A. Bukhary, Haitham A. Badr, Moutaz Y. Massadeh, Salam Alaamery, Manal Tawfik, Essam A. Pharmaceutics Article Geriatric patients are more likely to suffer from multiple chronic diseases that require using several drugs, which are commonly ingested. However, to enhance geriatric patients’ convenience, the electrospun nanofiber system was previously proven to be a successful alternative for the existing oral dosage forms, i.e., tablets and capsules. These nanofibers prepared either as single- or multi-layered fibers could hold at least one active compound in each layer. They might also be fabricated as ultra-disintegrated fibrous films for oral cavity administration, i.e., buccal or sublingual, to improve the bioavailability and intake of the administered drugs. Therefore, in this work, a combination of nifedipine and atorvastatin calcium, which are frequently prescribed for hypertension and hyperlipidemia patients, respectively, was prepared in a coaxial electrospinning system for buccal administration. Scanning electron microscopy image showed the successful preparation of smooth, non-beaded, and non-porous surfaces of the drug-loaded nanofibers with an average fiber diameter of 968 ± 198 nm. In contrast, transmission electron microscopy distinguished the inner and outer layers of those nanofibers. The disintegration of the drug-loaded nanofibers was ≤12 s, allowing the rapid release of nifedipine and atorvastatin calcium to 61% and 47%, respectively, after 10 min, while a complete drug release was achieved after 120 min. In vitro, a drug permeation study using Franz diffusion showed that the permeation of both drugs from the core–shell nanofibers was enhanced significantly (p < 0.05) compared to the drugs in a solution form. In conclusion, the development of drug-loaded nanofibers containing nifedipine and atorvastatin calcium can be a potential buccal delivery system. MDPI 2022-02-04 /pmc/articles/PMC8874982/ /pubmed/35214093 http://dx.doi.org/10.3390/pharmaceutics14020358 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alshaya, Hassa A.
Alfahad, Ahmed J.
Alsulaihem, Fatemah M.
Aodah, Alhassan H.
Alshehri, Abdullah A.
Almughem, Fahad A.
Alfassam, Haya A.
Aldossary, Ahmad M.
Halwani, Abdulrahman A.
Bukhary, Haitham A.
Badr, Moutaz Y.
Massadeh, Salam
Alaamery, Manal
Tawfik, Essam A.
Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal Delivery System
title Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal Delivery System
title_full Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal Delivery System
title_fullStr Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal Delivery System
title_full_unstemmed Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal Delivery System
title_short Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal Delivery System
title_sort fast-dissolving nifedipine and atorvastatin calcium electrospun nanofibers as a potential buccal delivery system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874982/
https://www.ncbi.nlm.nih.gov/pubmed/35214093
http://dx.doi.org/10.3390/pharmaceutics14020358
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