Cargando…

Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders

Metabolic disorders like diabetes mellitus, hypertension, dyslipidemia, and obesity are major medical problems globally. The incidence of these disorders has increased tremendously in recent years. Studies have demonstrated that plants with antioxidant and anti-inflammatory properties have beneficia...

Descripción completa

Detalles Bibliográficos
Autores principales: Siti, Hawa Nordin, Mohamed, Suhaila, Kamisah, Yusof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875002/
https://www.ncbi.nlm.nih.gov/pubmed/35215280
http://dx.doi.org/10.3390/ph15020167
_version_ 1784657821330046976
author Siti, Hawa Nordin
Mohamed, Suhaila
Kamisah, Yusof
author_facet Siti, Hawa Nordin
Mohamed, Suhaila
Kamisah, Yusof
author_sort Siti, Hawa Nordin
collection PubMed
description Metabolic disorders like diabetes mellitus, hypertension, dyslipidemia, and obesity are major medical problems globally. The incidence of these disorders has increased tremendously in recent years. Studies have demonstrated that plants with antioxidant and anti-inflammatory properties have beneficial effects on these disorders. One of these plants is Citrus hystrix DC, commonly known as kaffir lime. This review aims to present updates on the progress of research regarding the use of C. hystrix in metabolic disorders. Phytochemical compounds, including β-pinene, sabinene, citronellal, and citronellol, have been detected in the plant; and its extract exhibited potential antidiabetic, antihyperlipidemic and anti-obesity activity, as well as prevention of development of hypertension. These beneficial properties may be attributable to the presence of bioactive compounds which have therapeutic potential in treating these metabolic disorders. The compounds have the potential to be developed as candidate drugs. This review will assist in validating the regulatory role of the extract and its bioactive compounds on metabolic disorders, thus expediting future research in the area.
format Online
Article
Text
id pubmed-8875002
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88750022022-02-26 Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders Siti, Hawa Nordin Mohamed, Suhaila Kamisah, Yusof Pharmaceuticals (Basel) Review Metabolic disorders like diabetes mellitus, hypertension, dyslipidemia, and obesity are major medical problems globally. The incidence of these disorders has increased tremendously in recent years. Studies have demonstrated that plants with antioxidant and anti-inflammatory properties have beneficial effects on these disorders. One of these plants is Citrus hystrix DC, commonly known as kaffir lime. This review aims to present updates on the progress of research regarding the use of C. hystrix in metabolic disorders. Phytochemical compounds, including β-pinene, sabinene, citronellal, and citronellol, have been detected in the plant; and its extract exhibited potential antidiabetic, antihyperlipidemic and anti-obesity activity, as well as prevention of development of hypertension. These beneficial properties may be attributable to the presence of bioactive compounds which have therapeutic potential in treating these metabolic disorders. The compounds have the potential to be developed as candidate drugs. This review will assist in validating the regulatory role of the extract and its bioactive compounds on metabolic disorders, thus expediting future research in the area. MDPI 2022-01-29 /pmc/articles/PMC8875002/ /pubmed/35215280 http://dx.doi.org/10.3390/ph15020167 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Siti, Hawa Nordin
Mohamed, Suhaila
Kamisah, Yusof
Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders
title Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders
title_full Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders
title_fullStr Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders
title_full_unstemmed Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders
title_short Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders
title_sort potential therapeutic effects of citrus hystrix dc and its bioactive compounds on metabolic disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875002/
https://www.ncbi.nlm.nih.gov/pubmed/35215280
http://dx.doi.org/10.3390/ph15020167
work_keys_str_mv AT sitihawanordin potentialtherapeuticeffectsofcitrushystrixdcanditsbioactivecompoundsonmetabolicdisorders
AT mohamedsuhaila potentialtherapeuticeffectsofcitrushystrixdcanditsbioactivecompoundsonmetabolicdisorders
AT kamisahyusof potentialtherapeuticeffectsofcitrushystrixdcanditsbioactivecompoundsonmetabolicdisorders