Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France

In the autumn of 2020, a short-lived epidemic of a spike del69-70 deletion variant of SARS-CoV-2 was identified, with most cases (n = 95) found in Montceau-les-Mines, France. This spike gene target failure (SGTF) variant spread quickly in nursing homes. The Alpha variant, which also harbors this del...

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Detalles Bibliográficos
Autores principales: Giraudon, Hélène, Djemai, Mohand, Auvray, Christelle, de Rougemont, Alexis, Belliot, Gaël, Bour, Jean-Baptiste, Manoha, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875006/
https://www.ncbi.nlm.nih.gov/pubmed/35215068
http://dx.doi.org/10.3390/pathogens11020124
Descripción
Sumario:In the autumn of 2020, a short-lived epidemic of a spike del69-70 deletion variant of SARS-CoV-2 was identified, with most cases (n = 95) found in Montceau-les-Mines, France. This spike gene target failure (SGTF) variant spread quickly in nursing homes. The Alpha variant, which also harbors this deletion, appeared in Burgundy in January 2021 after the disappearance of the Montceau-les-Mines del69-70 variant. Our findings illustrate the risk of the fast spread of geographically isolated variants and reinforce the need for the continuous tracking of outbreaks. In some cases, these studies may reveal emerging variants that affect public health or vaccine development.

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