Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France

In the autumn of 2020, a short-lived epidemic of a spike del69-70 deletion variant of SARS-CoV-2 was identified, with most cases (n = 95) found in Montceau-les-Mines, France. This spike gene target failure (SGTF) variant spread quickly in nursing homes. The Alpha variant, which also harbors this del...

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Autores principales: Giraudon, Hélène, Djemai, Mohand, Auvray, Christelle, de Rougemont, Alexis, Belliot, Gaël, Bour, Jean-Baptiste, Manoha, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875006/
https://www.ncbi.nlm.nih.gov/pubmed/35215068
http://dx.doi.org/10.3390/pathogens11020124
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author Giraudon, Hélène
Djemai, Mohand
Auvray, Christelle
de Rougemont, Alexis
Belliot, Gaël
Bour, Jean-Baptiste
Manoha, Catherine
author_facet Giraudon, Hélène
Djemai, Mohand
Auvray, Christelle
de Rougemont, Alexis
Belliot, Gaël
Bour, Jean-Baptiste
Manoha, Catherine
author_sort Giraudon, Hélène
collection PubMed
description In the autumn of 2020, a short-lived epidemic of a spike del69-70 deletion variant of SARS-CoV-2 was identified, with most cases (n = 95) found in Montceau-les-Mines, France. This spike gene target failure (SGTF) variant spread quickly in nursing homes. The Alpha variant, which also harbors this deletion, appeared in Burgundy in January 2021 after the disappearance of the Montceau-les-Mines del69-70 variant. Our findings illustrate the risk of the fast spread of geographically isolated variants and reinforce the need for the continuous tracking of outbreaks. In some cases, these studies may reveal emerging variants that affect public health or vaccine development.
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spelling pubmed-88750062022-02-26 Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France Giraudon, Hélène Djemai, Mohand Auvray, Christelle de Rougemont, Alexis Belliot, Gaël Bour, Jean-Baptiste Manoha, Catherine Pathogens Brief Report In the autumn of 2020, a short-lived epidemic of a spike del69-70 deletion variant of SARS-CoV-2 was identified, with most cases (n = 95) found in Montceau-les-Mines, France. This spike gene target failure (SGTF) variant spread quickly in nursing homes. The Alpha variant, which also harbors this deletion, appeared in Burgundy in January 2021 after the disappearance of the Montceau-les-Mines del69-70 variant. Our findings illustrate the risk of the fast spread of geographically isolated variants and reinforce the need for the continuous tracking of outbreaks. In some cases, these studies may reveal emerging variants that affect public health or vaccine development. MDPI 2022-01-20 /pmc/articles/PMC8875006/ /pubmed/35215068 http://dx.doi.org/10.3390/pathogens11020124 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Giraudon, Hélène
Djemai, Mohand
Auvray, Christelle
de Rougemont, Alexis
Belliot, Gaël
Bour, Jean-Baptiste
Manoha, Catherine
Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France
title Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France
title_full Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France
title_fullStr Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France
title_full_unstemmed Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France
title_short Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France
title_sort local emergence of a del hv69-70 sars-cov-2 variant in burgundy, france
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875006/
https://www.ncbi.nlm.nih.gov/pubmed/35215068
http://dx.doi.org/10.3390/pathogens11020124
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