Engineered Zinc Finger Protein Targeting 2LTR Inhibits HIV Integration in Hematopoietic Stem and Progenitor Cell-Derived Macrophages: In Vitro Study

Human hematopoietic stem/progenitor cell (HSPC)-based gene therapy is a promising direction for curing HIV-1-infected individuals. The zinc finger protein (2LTRZFP) designed to target the 2-LTR-circle junction of HIV-1 cDNA was previously reported as an intracellular antiviral molecular scaffold tha...

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Detalles Bibliográficos
Autores principales: Chupradit, Koollawat, Khamaikawin, Wannisa, Sakkhachornphop, Supachai, Puaninta, Chaniporn, Torbett, Bruce E., Borwornpinyo, Suparerk, Hongeng, Suradej, Wattanapanitch, Methichit, Tayapiwatana, Chatchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875109/
https://www.ncbi.nlm.nih.gov/pubmed/35216446
http://dx.doi.org/10.3390/ijms23042331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875109/
https://www.ncbi.nlm.nih.gov/pubmed/35216446
http://dx.doi.org/10.3390/ijms23042331

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