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Role of Cellular Metabolism during Candida-Host Interactions

Microscopic fungi are widely present in the environment and, more importantly, are also an essential part of the human healthy mycobiota. However, many species can become pathogenic under certain circumstances, with Candida spp. being the most clinically relevant fungi. In recent years, the importan...

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Autores principales: Pellon, Aize, Begum, Neelu, Sadeghi Nasab, Shervin Dokht, Harzandi, Azadeh, Shoaie, Saeed, Moyes, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875223/
https://www.ncbi.nlm.nih.gov/pubmed/35215128
http://dx.doi.org/10.3390/pathogens11020184
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author Pellon, Aize
Begum, Neelu
Sadeghi Nasab, Shervin Dokht
Harzandi, Azadeh
Shoaie, Saeed
Moyes, David L.
author_facet Pellon, Aize
Begum, Neelu
Sadeghi Nasab, Shervin Dokht
Harzandi, Azadeh
Shoaie, Saeed
Moyes, David L.
author_sort Pellon, Aize
collection PubMed
description Microscopic fungi are widely present in the environment and, more importantly, are also an essential part of the human healthy mycobiota. However, many species can become pathogenic under certain circumstances, with Candida spp. being the most clinically relevant fungi. In recent years, the importance of metabolism and nutrient availability for fungi-host interactions have been highlighted. Upon activation, immune and other host cells reshape their metabolism to fulfil the energy-demanding process of generating an immune response. This includes macrophage upregulation of glucose uptake and processing via aerobic glycolysis. On the other side, Candida modulates its metabolic pathways to adapt to the usually hostile environment in the host, such as the lumen of phagolysosomes. Further understanding on metabolic interactions between host and fungal cells would potentially lead to novel/enhanced antifungal therapies to fight these infections. Therefore, this review paper focuses on how cellular metabolism, of both host cells and Candida, and the nutritional environment impact on the interplay between host and fungal cells.
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spelling pubmed-88752232022-02-26 Role of Cellular Metabolism during Candida-Host Interactions Pellon, Aize Begum, Neelu Sadeghi Nasab, Shervin Dokht Harzandi, Azadeh Shoaie, Saeed Moyes, David L. Pathogens Review Microscopic fungi are widely present in the environment and, more importantly, are also an essential part of the human healthy mycobiota. However, many species can become pathogenic under certain circumstances, with Candida spp. being the most clinically relevant fungi. In recent years, the importance of metabolism and nutrient availability for fungi-host interactions have been highlighted. Upon activation, immune and other host cells reshape their metabolism to fulfil the energy-demanding process of generating an immune response. This includes macrophage upregulation of glucose uptake and processing via aerobic glycolysis. On the other side, Candida modulates its metabolic pathways to adapt to the usually hostile environment in the host, such as the lumen of phagolysosomes. Further understanding on metabolic interactions between host and fungal cells would potentially lead to novel/enhanced antifungal therapies to fight these infections. Therefore, this review paper focuses on how cellular metabolism, of both host cells and Candida, and the nutritional environment impact on the interplay between host and fungal cells. MDPI 2022-01-28 /pmc/articles/PMC8875223/ /pubmed/35215128 http://dx.doi.org/10.3390/pathogens11020184 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pellon, Aize
Begum, Neelu
Sadeghi Nasab, Shervin Dokht
Harzandi, Azadeh
Shoaie, Saeed
Moyes, David L.
Role of Cellular Metabolism during Candida-Host Interactions
title Role of Cellular Metabolism during Candida-Host Interactions
title_full Role of Cellular Metabolism during Candida-Host Interactions
title_fullStr Role of Cellular Metabolism during Candida-Host Interactions
title_full_unstemmed Role of Cellular Metabolism during Candida-Host Interactions
title_short Role of Cellular Metabolism during Candida-Host Interactions
title_sort role of cellular metabolism during candida-host interactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875223/
https://www.ncbi.nlm.nih.gov/pubmed/35215128
http://dx.doi.org/10.3390/pathogens11020184
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