The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity

This work describes the activity of 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX) and of its newly identified carboxylic acid metabolite on the human malaria parasite Plasmodium falciparum. NBDHEX has been previously identified as a potent cytotoxic agent against murine and human...

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Detalles Bibliográficos
Autores principales: Siciliano, Giulia, Di Paolo, Veronica, Rotili, Dante, Migale, Rossella, Pedini, Francesca, Casella, Marialuisa, Camerini, Serena, Dalzoppo, Daniele, Henderson, Rob, Huijs, Tonnie, Dechering, Koen J., Mai, Antonello, Caccuri, Anna Maria, Lalle, Marco, Quintieri, Luigi, Alano, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875241/
https://www.ncbi.nlm.nih.gov/pubmed/35215282
http://dx.doi.org/10.3390/ph15020168

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