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Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China

This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH and 53 HIV-negative individuals aged 18–59 years who had received an inactivated SARS-CoV-2 vaccine in two Chinese cities between April...

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Autores principales: Huang, Xiaojie, Yan, Ying, Su, Bin, Xiao, Dong, Yu, Maohe, Jin, Xia, Duan, Junyi, Zhang, Xiangjun, Zheng, Shimin, Fang, Yuan, Zhang, Tong, Tang, Weiming, Wang, Lunan, Wang, Zixin, Xu, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875274/
https://www.ncbi.nlm.nih.gov/pubmed/35215870
http://dx.doi.org/10.3390/v14020277
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author Huang, Xiaojie
Yan, Ying
Su, Bin
Xiao, Dong
Yu, Maohe
Jin, Xia
Duan, Junyi
Zhang, Xiangjun
Zheng, Shimin
Fang, Yuan
Zhang, Tong
Tang, Weiming
Wang, Lunan
Wang, Zixin
Xu, Junjie
author_facet Huang, Xiaojie
Yan, Ying
Su, Bin
Xiao, Dong
Yu, Maohe
Jin, Xia
Duan, Junyi
Zhang, Xiangjun
Zheng, Shimin
Fang, Yuan
Zhang, Tong
Tang, Weiming
Wang, Lunan
Wang, Zixin
Xu, Junjie
author_sort Huang, Xiaojie
collection PubMed
description This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH and 53 HIV-negative individuals aged 18–59 years who had received an inactivated SARS-CoV-2 vaccine in two Chinese cities between April and June 2021. Blood samples were tested for immunogenicity of the inactivated SARS-CoV-2 vaccines. The prevalence and severity of adverse events associated with SARS-CoV-2 vaccines were similar between PLWH and HIV-negative individuals. The seropositivity of neutralizing activity against authentic SARS-CoV-2, of the total amount of antibody (total antibody) and of S-IgG were 71.3%, 81.9%, and 92.6%, respectively, among fully vaccinated PLWH. Among all participants, PLWH had lower neutralizing activity, total antibody, S-IgG, and T-cell-specific immune response levels, compared to HIV-negative individuals, after controlling for types of vaccine, time interval between first and second dose, time after receiving the second dose, and sociodemographic factors. PLWH with a longer interval since HIV diagnosis, who received their second dose 15–28 days prior to study commencement, and who had an interval of ≥21 days between first and second dose had higher neutralizing activity levels. The immunogenicity of the inactivated SARS-CoV-2 vaccines was lower among PLWH as compared to HIV-negative individuals. Vaccination guideline specific for PLWH should be developed.
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spelling pubmed-88752742022-02-26 Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China Huang, Xiaojie Yan, Ying Su, Bin Xiao, Dong Yu, Maohe Jin, Xia Duan, Junyi Zhang, Xiangjun Zheng, Shimin Fang, Yuan Zhang, Tong Tang, Weiming Wang, Lunan Wang, Zixin Xu, Junjie Viruses Article This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH and 53 HIV-negative individuals aged 18–59 years who had received an inactivated SARS-CoV-2 vaccine in two Chinese cities between April and June 2021. Blood samples were tested for immunogenicity of the inactivated SARS-CoV-2 vaccines. The prevalence and severity of adverse events associated with SARS-CoV-2 vaccines were similar between PLWH and HIV-negative individuals. The seropositivity of neutralizing activity against authentic SARS-CoV-2, of the total amount of antibody (total antibody) and of S-IgG were 71.3%, 81.9%, and 92.6%, respectively, among fully vaccinated PLWH. Among all participants, PLWH had lower neutralizing activity, total antibody, S-IgG, and T-cell-specific immune response levels, compared to HIV-negative individuals, after controlling for types of vaccine, time interval between first and second dose, time after receiving the second dose, and sociodemographic factors. PLWH with a longer interval since HIV diagnosis, who received their second dose 15–28 days prior to study commencement, and who had an interval of ≥21 days between first and second dose had higher neutralizing activity levels. The immunogenicity of the inactivated SARS-CoV-2 vaccines was lower among PLWH as compared to HIV-negative individuals. Vaccination guideline specific for PLWH should be developed. MDPI 2022-01-28 /pmc/articles/PMC8875274/ /pubmed/35215870 http://dx.doi.org/10.3390/v14020277 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Xiaojie
Yan, Ying
Su, Bin
Xiao, Dong
Yu, Maohe
Jin, Xia
Duan, Junyi
Zhang, Xiangjun
Zheng, Shimin
Fang, Yuan
Zhang, Tong
Tang, Weiming
Wang, Lunan
Wang, Zixin
Xu, Junjie
Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China
title Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China
title_full Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China
title_fullStr Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China
title_full_unstemmed Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China
title_short Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China
title_sort comparing immune responses to inactivated vaccines against sars-cov-2 between people living with hiv and hiv-negative individuals: a cross-sectional study in china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875274/
https://www.ncbi.nlm.nih.gov/pubmed/35215870
http://dx.doi.org/10.3390/v14020277
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