Cargando…

Smoking Obstructive Sleep Apnea: Arguments for a Distinctive Phenotype and a Personalized Intervention

Background: This is the first study that aims to define smoking, with obstructive sleep apnea (OSA), as a phenotype (SOSA). Moreover, we wanted to demonstrate the deleterious effects of the continuation of smoking on OSA. Methods: The cross-sectional study highlighted four dimensions of SOSA: the de...

Descripción completa

Detalles Bibliográficos
Autores principales: Oțelea, Marina Ruxandra, Trenchea, Mihaela, Rașcu, Agripina, Antoniu, Sabina, Zugravu, Corina, Busnatu, Ștefan, Simionescu, Anca Angela, Arghir, Oana Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875333/
https://www.ncbi.nlm.nih.gov/pubmed/35207781
http://dx.doi.org/10.3390/jpm12020293
_version_ 1784657887807668224
author Oțelea, Marina Ruxandra
Trenchea, Mihaela
Rașcu, Agripina
Antoniu, Sabina
Zugravu, Corina
Busnatu, Ștefan
Simionescu, Anca Angela
Arghir, Oana Cristina
author_facet Oțelea, Marina Ruxandra
Trenchea, Mihaela
Rașcu, Agripina
Antoniu, Sabina
Zugravu, Corina
Busnatu, Ștefan
Simionescu, Anca Angela
Arghir, Oana Cristina
author_sort Oțelea, Marina Ruxandra
collection PubMed
description Background: This is the first study that aims to define smoking, with obstructive sleep apnea (OSA), as a phenotype (SOSA). Moreover, we wanted to demonstrate the deleterious effects of the continuation of smoking on OSA. Methods: The cross-sectional study highlighted four dimensions of SOSA: the demographic and anthropometric features, the symptoms, the comorbidities, and the sleep study parameters. This study compared these characteristics between current smokers (CS), those who have never smoked (NS), and ex-smokers (ES) with OSA. Results: More men (83.95% in CS, versus 66.67% in NS) and an earlier onset of OSA (average age = 50.05 in CS, versus 52.26 in NS, p = 0.04) were recorded among CS. The distinguishing symptom of CS was daytime sleepiness, with an Epworth score that was significantly higher than in NS. Chronic obstructive pulmonary disease (COPD) was significantly more prevalent in CS (38.27%) than in NS (1.51%) (p < 0.001). The severity of OSA, consisting of a higher apnea-hypopnea index, a higher oxygen desaturation index, and a longer time spent below 90% oxygen saturation during sleep was significantly influenced by smoking. Conclusions: The SOSA phenotype includes younger male patients with a higher waist circumference, suggesting central obesity. They have a higher prevalence of COPD and a greater severity of OSA, in correlation with the number of pack-years of smoking.
format Online
Article
Text
id pubmed-8875333
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88753332022-02-26 Smoking Obstructive Sleep Apnea: Arguments for a Distinctive Phenotype and a Personalized Intervention Oțelea, Marina Ruxandra Trenchea, Mihaela Rașcu, Agripina Antoniu, Sabina Zugravu, Corina Busnatu, Ștefan Simionescu, Anca Angela Arghir, Oana Cristina J Pers Med Article Background: This is the first study that aims to define smoking, with obstructive sleep apnea (OSA), as a phenotype (SOSA). Moreover, we wanted to demonstrate the deleterious effects of the continuation of smoking on OSA. Methods: The cross-sectional study highlighted four dimensions of SOSA: the demographic and anthropometric features, the symptoms, the comorbidities, and the sleep study parameters. This study compared these characteristics between current smokers (CS), those who have never smoked (NS), and ex-smokers (ES) with OSA. Results: More men (83.95% in CS, versus 66.67% in NS) and an earlier onset of OSA (average age = 50.05 in CS, versus 52.26 in NS, p = 0.04) were recorded among CS. The distinguishing symptom of CS was daytime sleepiness, with an Epworth score that was significantly higher than in NS. Chronic obstructive pulmonary disease (COPD) was significantly more prevalent in CS (38.27%) than in NS (1.51%) (p < 0.001). The severity of OSA, consisting of a higher apnea-hypopnea index, a higher oxygen desaturation index, and a longer time spent below 90% oxygen saturation during sleep was significantly influenced by smoking. Conclusions: The SOSA phenotype includes younger male patients with a higher waist circumference, suggesting central obesity. They have a higher prevalence of COPD and a greater severity of OSA, in correlation with the number of pack-years of smoking. MDPI 2022-02-16 /pmc/articles/PMC8875333/ /pubmed/35207781 http://dx.doi.org/10.3390/jpm12020293 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oțelea, Marina Ruxandra
Trenchea, Mihaela
Rașcu, Agripina
Antoniu, Sabina
Zugravu, Corina
Busnatu, Ștefan
Simionescu, Anca Angela
Arghir, Oana Cristina
Smoking Obstructive Sleep Apnea: Arguments for a Distinctive Phenotype and a Personalized Intervention
title Smoking Obstructive Sleep Apnea: Arguments for a Distinctive Phenotype and a Personalized Intervention
title_full Smoking Obstructive Sleep Apnea: Arguments for a Distinctive Phenotype and a Personalized Intervention
title_fullStr Smoking Obstructive Sleep Apnea: Arguments for a Distinctive Phenotype and a Personalized Intervention
title_full_unstemmed Smoking Obstructive Sleep Apnea: Arguments for a Distinctive Phenotype and a Personalized Intervention
title_short Smoking Obstructive Sleep Apnea: Arguments for a Distinctive Phenotype and a Personalized Intervention
title_sort smoking obstructive sleep apnea: arguments for a distinctive phenotype and a personalized intervention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875333/
https://www.ncbi.nlm.nih.gov/pubmed/35207781
http://dx.doi.org/10.3390/jpm12020293
work_keys_str_mv AT oteleamarinaruxandra smokingobstructivesleepapneaargumentsforadistinctivephenotypeandapersonalizedintervention
AT trencheamihaela smokingobstructivesleepapneaargumentsforadistinctivephenotypeandapersonalizedintervention
AT rascuagripina smokingobstructivesleepapneaargumentsforadistinctivephenotypeandapersonalizedintervention
AT antoniusabina smokingobstructivesleepapneaargumentsforadistinctivephenotypeandapersonalizedintervention
AT zugravucorina smokingobstructivesleepapneaargumentsforadistinctivephenotypeandapersonalizedintervention
AT busnatustefan smokingobstructivesleepapneaargumentsforadistinctivephenotypeandapersonalizedintervention
AT simionescuancaangela smokingobstructivesleepapneaargumentsforadistinctivephenotypeandapersonalizedintervention
AT arghiroanacristina smokingobstructivesleepapneaargumentsforadistinctivephenotypeandapersonalizedintervention