Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia

[Image: see text] Cryogenic electron microscopy (cryo-EM) has emerged as a viable structural tool for molecular therapeutics development against human diseases. However, it remains a challenge to determine structures of proteins that are flexible and smaller than 30 kDa. The 11 kDa KIX domain of CRE...

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Detalles Bibliográficos
Autores principales: Zhang, Kaiming, Horikoshi, Naoki, Li, Shanshan, Powers, Alexander S., Hameedi, Mikhail A., Pintilie, Grigore D., Chae, Hee-Don, Khan, Yousuf A., Suomivuori, Carl-Mikael, Dror, Ron O., Sakamoto, Kathleen M., Chiu, Wah, Wakatsuki, Soichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875425/
https://www.ncbi.nlm.nih.gov/pubmed/35233453
http://dx.doi.org/10.1021/acscentsci.1c01090

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