Vectorial Release of Human RNA Viruses from Epithelial Cells

Epithelial cells are apico-basolateral polarized cells that line all tubular organs and are often targets for infectious agents. This review focuses on the release of human RNA virus particles from both sides of polarized human cells grown on transwells. Most viruses that infect the mucosa leave the...

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Autores principales: Chapuy-Regaud, Sabine, Allioux, Claire, Capelli, Nicolas, Migueres, Marion, Lhomme, Sébastien, Izopet, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875463/
https://www.ncbi.nlm.nih.gov/pubmed/35215825
http://dx.doi.org/10.3390/v14020231
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author Chapuy-Regaud, Sabine
Allioux, Claire
Capelli, Nicolas
Migueres, Marion
Lhomme, Sébastien
Izopet, Jacques
author_facet Chapuy-Regaud, Sabine
Allioux, Claire
Capelli, Nicolas
Migueres, Marion
Lhomme, Sébastien
Izopet, Jacques
author_sort Chapuy-Regaud, Sabine
collection PubMed
description Epithelial cells are apico-basolateral polarized cells that line all tubular organs and are often targets for infectious agents. This review focuses on the release of human RNA virus particles from both sides of polarized human cells grown on transwells. Most viruses that infect the mucosa leave their host cells mainly via the apical side while basolateral release is linked to virus propagation within the host. Viruses do this by hijacking the cellular factors involved in polarization and trafficking. Thus, understanding epithelial polarization is essential for a clear understanding of virus pathophysiology.
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spelling pubmed-88754632022-02-26 Vectorial Release of Human RNA Viruses from Epithelial Cells Chapuy-Regaud, Sabine Allioux, Claire Capelli, Nicolas Migueres, Marion Lhomme, Sébastien Izopet, Jacques Viruses Review Epithelial cells are apico-basolateral polarized cells that line all tubular organs and are often targets for infectious agents. This review focuses on the release of human RNA virus particles from both sides of polarized human cells grown on transwells. Most viruses that infect the mucosa leave their host cells mainly via the apical side while basolateral release is linked to virus propagation within the host. Viruses do this by hijacking the cellular factors involved in polarization and trafficking. Thus, understanding epithelial polarization is essential for a clear understanding of virus pathophysiology. MDPI 2022-01-25 /pmc/articles/PMC8875463/ /pubmed/35215825 http://dx.doi.org/10.3390/v14020231 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chapuy-Regaud, Sabine
Allioux, Claire
Capelli, Nicolas
Migueres, Marion
Lhomme, Sébastien
Izopet, Jacques
Vectorial Release of Human RNA Viruses from Epithelial Cells
title Vectorial Release of Human RNA Viruses from Epithelial Cells
title_full Vectorial Release of Human RNA Viruses from Epithelial Cells
title_fullStr Vectorial Release of Human RNA Viruses from Epithelial Cells
title_full_unstemmed Vectorial Release of Human RNA Viruses from Epithelial Cells
title_short Vectorial Release of Human RNA Viruses from Epithelial Cells
title_sort vectorial release of human rna viruses from epithelial cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875463/
https://www.ncbi.nlm.nih.gov/pubmed/35215825
http://dx.doi.org/10.3390/v14020231
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