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Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity

Recent studies have shown that the gut microbiota plays an important role in the pathogenesis of gastrointestinal diseases in various animal species. There are only limited data on the microbiome in cats with varying grades of dysbiosis. The purpose of the study was a detailed analysis of the quanti...

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Autores principales: Bugrov, Nikolay, Rudenko, Pavel, Lutsay, Vladimir, Gurina, Regina, Zharov, Andrey, Khairova, Nadiya, Molchanova, Maria, Krotova, Elena, Shopinskaya, Marina, Bolshakova, Marina, Popova, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875498/
https://www.ncbi.nlm.nih.gov/pubmed/35215175
http://dx.doi.org/10.3390/pathogens11020234
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author Bugrov, Nikolay
Rudenko, Pavel
Lutsay, Vladimir
Gurina, Regina
Zharov, Andrey
Khairova, Nadiya
Molchanova, Maria
Krotova, Elena
Shopinskaya, Marina
Bolshakova, Marina
Popova, Irina
author_facet Bugrov, Nikolay
Rudenko, Pavel
Lutsay, Vladimir
Gurina, Regina
Zharov, Andrey
Khairova, Nadiya
Molchanova, Maria
Krotova, Elena
Shopinskaya, Marina
Bolshakova, Marina
Popova, Irina
author_sort Bugrov, Nikolay
collection PubMed
description Recent studies have shown that the gut microbiota plays an important role in the pathogenesis of gastrointestinal diseases in various animal species. There are only limited data on the microbiome in cats with varying grades of dysbiosis. The purpose of the study was a detailed analysis of the quantitative and qualitative fecal microbiota spectrum in cats with intestinal dysbiosis of varying severity. The data obtained indicate that, depending on the dysbiosis severity in cats, the intestinal microbiome landscape changes significantly. It has been established that, depending on the dysbiosis severity, there is a shift in the balance between the Gram-positive and Gram-negative bacterial pools and in the nature of the isolation of specific bacteria forms, in the amount of obligate microbiota isolation, as well as individual facultative strains. When analyzing the serotyping of E. coli cultures isolated at various grades of intestinal dysbiosis severity, differences were found both in the isolation amount of various serotypes from one animal and in the prevalence of certain serotypes for each disease severity. A retrospective analysis of the fecal microbiota sensitivity in cats with dysbiosis to antibacterial drugs showed that, depending on the disease severity, the number of isolates sensitive to antibiotics increases significantly.
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spelling pubmed-88754982022-02-26 Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity Bugrov, Nikolay Rudenko, Pavel Lutsay, Vladimir Gurina, Regina Zharov, Andrey Khairova, Nadiya Molchanova, Maria Krotova, Elena Shopinskaya, Marina Bolshakova, Marina Popova, Irina Pathogens Article Recent studies have shown that the gut microbiota plays an important role in the pathogenesis of gastrointestinal diseases in various animal species. There are only limited data on the microbiome in cats with varying grades of dysbiosis. The purpose of the study was a detailed analysis of the quantitative and qualitative fecal microbiota spectrum in cats with intestinal dysbiosis of varying severity. The data obtained indicate that, depending on the dysbiosis severity in cats, the intestinal microbiome landscape changes significantly. It has been established that, depending on the dysbiosis severity, there is a shift in the balance between the Gram-positive and Gram-negative bacterial pools and in the nature of the isolation of specific bacteria forms, in the amount of obligate microbiota isolation, as well as individual facultative strains. When analyzing the serotyping of E. coli cultures isolated at various grades of intestinal dysbiosis severity, differences were found both in the isolation amount of various serotypes from one animal and in the prevalence of certain serotypes for each disease severity. A retrospective analysis of the fecal microbiota sensitivity in cats with dysbiosis to antibacterial drugs showed that, depending on the disease severity, the number of isolates sensitive to antibiotics increases significantly. MDPI 2022-02-10 /pmc/articles/PMC8875498/ /pubmed/35215175 http://dx.doi.org/10.3390/pathogens11020234 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bugrov, Nikolay
Rudenko, Pavel
Lutsay, Vladimir
Gurina, Regina
Zharov, Andrey
Khairova, Nadiya
Molchanova, Maria
Krotova, Elena
Shopinskaya, Marina
Bolshakova, Marina
Popova, Irina
Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity
title Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity
title_full Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity
title_fullStr Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity
title_full_unstemmed Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity
title_short Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity
title_sort fecal microbiota analysis in cats with intestinal dysbiosis of varying severity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875498/
https://www.ncbi.nlm.nih.gov/pubmed/35215175
http://dx.doi.org/10.3390/pathogens11020234
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