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Effects of Ultramicronized N-Palmitoylethanolamine Supplementation on Tramadol and Oxycodone Analgesia and Tolerance Prevention

Chronic pain management requires increasing doses of opioids, the milestone of painkillers, which may result in the onset of tolerance with exacerbated side effects. Maintaining stable analgesia with low doses of opioids is thus imperative. N-palmitoylethanolamine (PEA) is an endogenous lipid compou...

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Detalles Bibliográficos
Autores principales:	Micheli, Laura, Lucarini, Elena, Toti, Alessandra, Ferrara, Valentina, Ciampi, Clara, Parisio, Carmen, Bartolucci, Gianluca, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875545/ https://www.ncbi.nlm.nih.gov/pubmed/35214131 http://dx.doi.org/10.3390/pharmaceutics14020403

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