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HELLP Syndrome—Holistic Insight into Pathophysiology
HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2–0.8% of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875732/ https://www.ncbi.nlm.nih.gov/pubmed/35208649 http://dx.doi.org/10.3390/medicina58020326 |
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author | Petca, Aida Miron, Bianca Corina Pacu, Irina Dumitrașcu, Mihai Cristian Mehedințu, Claudia Șandru, Florica Petca, Răzvan-Cosmin Rotar, Ioana Cristina |
author_facet | Petca, Aida Miron, Bianca Corina Pacu, Irina Dumitrașcu, Mihai Cristian Mehedințu, Claudia Șandru, Florica Petca, Răzvan-Cosmin Rotar, Ioana Cristina |
author_sort | Petca, Aida |
collection | PubMed |
description | HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2–0.8% of pregnancies, and, in 70–80% of cases, it coexists with preeclampsia (PE). Both of these conditions show a familial tendency. A woman with a history of HELLP pregnancy is at high risk for developing this entity in subsequent pregnancies. We cannot nominate a single worldwide genetic cause for the increased risk of HELLP. Combinations of multiple gene variants, each with a moderate risk, with concurrent maternal and environmental factors are thought to be the etiological mechanisms. This review highlights the significant role of understanding the underlying pathophysiological mechanism of HELLP syndrome. A better knowledge of the disease’s course supports early detection, an accurate diagnosis, and proper management of this life-threatening condition. |
format | Online Article Text |
id | pubmed-8875732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88757322022-02-26 HELLP Syndrome—Holistic Insight into Pathophysiology Petca, Aida Miron, Bianca Corina Pacu, Irina Dumitrașcu, Mihai Cristian Mehedințu, Claudia Șandru, Florica Petca, Răzvan-Cosmin Rotar, Ioana Cristina Medicina (Kaunas) Review HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2–0.8% of pregnancies, and, in 70–80% of cases, it coexists with preeclampsia (PE). Both of these conditions show a familial tendency. A woman with a history of HELLP pregnancy is at high risk for developing this entity in subsequent pregnancies. We cannot nominate a single worldwide genetic cause for the increased risk of HELLP. Combinations of multiple gene variants, each with a moderate risk, with concurrent maternal and environmental factors are thought to be the etiological mechanisms. This review highlights the significant role of understanding the underlying pathophysiological mechanism of HELLP syndrome. A better knowledge of the disease’s course supports early detection, an accurate diagnosis, and proper management of this life-threatening condition. MDPI 2022-02-21 /pmc/articles/PMC8875732/ /pubmed/35208649 http://dx.doi.org/10.3390/medicina58020326 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Petca, Aida Miron, Bianca Corina Pacu, Irina Dumitrașcu, Mihai Cristian Mehedințu, Claudia Șandru, Florica Petca, Răzvan-Cosmin Rotar, Ioana Cristina HELLP Syndrome—Holistic Insight into Pathophysiology |
title | HELLP Syndrome—Holistic Insight into Pathophysiology |
title_full | HELLP Syndrome—Holistic Insight into Pathophysiology |
title_fullStr | HELLP Syndrome—Holistic Insight into Pathophysiology |
title_full_unstemmed | HELLP Syndrome—Holistic Insight into Pathophysiology |
title_short | HELLP Syndrome—Holistic Insight into Pathophysiology |
title_sort | hellp syndrome—holistic insight into pathophysiology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875732/ https://www.ncbi.nlm.nih.gov/pubmed/35208649 http://dx.doi.org/10.3390/medicina58020326 |
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