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HELLP Syndrome—Holistic Insight into Pathophysiology

HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2–0.8% of...

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Autores principales: Petca, Aida, Miron, Bianca Corina, Pacu, Irina, Dumitrașcu, Mihai Cristian, Mehedințu, Claudia, Șandru, Florica, Petca, Răzvan-Cosmin, Rotar, Ioana Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875732/
https://www.ncbi.nlm.nih.gov/pubmed/35208649
http://dx.doi.org/10.3390/medicina58020326
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author Petca, Aida
Miron, Bianca Corina
Pacu, Irina
Dumitrașcu, Mihai Cristian
Mehedințu, Claudia
Șandru, Florica
Petca, Răzvan-Cosmin
Rotar, Ioana Cristina
author_facet Petca, Aida
Miron, Bianca Corina
Pacu, Irina
Dumitrașcu, Mihai Cristian
Mehedințu, Claudia
Șandru, Florica
Petca, Răzvan-Cosmin
Rotar, Ioana Cristina
author_sort Petca, Aida
collection PubMed
description HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2–0.8% of pregnancies, and, in 70–80% of cases, it coexists with preeclampsia (PE). Both of these conditions show a familial tendency. A woman with a history of HELLP pregnancy is at high risk for developing this entity in subsequent pregnancies. We cannot nominate a single worldwide genetic cause for the increased risk of HELLP. Combinations of multiple gene variants, each with a moderate risk, with concurrent maternal and environmental factors are thought to be the etiological mechanisms. This review highlights the significant role of understanding the underlying pathophysiological mechanism of HELLP syndrome. A better knowledge of the disease’s course supports early detection, an accurate diagnosis, and proper management of this life-threatening condition.
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spelling pubmed-88757322022-02-26 HELLP Syndrome—Holistic Insight into Pathophysiology Petca, Aida Miron, Bianca Corina Pacu, Irina Dumitrașcu, Mihai Cristian Mehedințu, Claudia Șandru, Florica Petca, Răzvan-Cosmin Rotar, Ioana Cristina Medicina (Kaunas) Review HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2–0.8% of pregnancies, and, in 70–80% of cases, it coexists with preeclampsia (PE). Both of these conditions show a familial tendency. A woman with a history of HELLP pregnancy is at high risk for developing this entity in subsequent pregnancies. We cannot nominate a single worldwide genetic cause for the increased risk of HELLP. Combinations of multiple gene variants, each with a moderate risk, with concurrent maternal and environmental factors are thought to be the etiological mechanisms. This review highlights the significant role of understanding the underlying pathophysiological mechanism of HELLP syndrome. A better knowledge of the disease’s course supports early detection, an accurate diagnosis, and proper management of this life-threatening condition. MDPI 2022-02-21 /pmc/articles/PMC8875732/ /pubmed/35208649 http://dx.doi.org/10.3390/medicina58020326 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Petca, Aida
Miron, Bianca Corina
Pacu, Irina
Dumitrașcu, Mihai Cristian
Mehedințu, Claudia
Șandru, Florica
Petca, Răzvan-Cosmin
Rotar, Ioana Cristina
HELLP Syndrome—Holistic Insight into Pathophysiology
title HELLP Syndrome—Holistic Insight into Pathophysiology
title_full HELLP Syndrome—Holistic Insight into Pathophysiology
title_fullStr HELLP Syndrome—Holistic Insight into Pathophysiology
title_full_unstemmed HELLP Syndrome—Holistic Insight into Pathophysiology
title_short HELLP Syndrome—Holistic Insight into Pathophysiology
title_sort hellp syndrome—holistic insight into pathophysiology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875732/
https://www.ncbi.nlm.nih.gov/pubmed/35208649
http://dx.doi.org/10.3390/medicina58020326
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