Cargando…

Associations between RNA-Binding Motif Protein 3, Fibroblast Growth Factor 21, and Clinical Outcome in Patients with Stroke

Background: RNA-binding motif protein 3 (RBM3) is a cold-induced marker of good functional outcome of ischemic stroke that is promising as a protective target. Fibroblast growth factor 21 (FGF21) is an obesity- and temperature-related hormone that upregulates the expression of RBM3, which is benefic...

Descripción completa

Detalles Bibliográficos
Autores principales: Ávila-Gómez, Paulo, Pérez-Mato, María, Hervella, Pablo, Dopico-López, Antonio, da Silva-Candal, Andrés, Bugallo-Casal, Ana, López-Amoedo, Sonia, Candamo-Lourido, María, Sobrino, Tomás, Iglesias-Rey, Ramón, Castillo, José, Campos, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875775/
https://www.ncbi.nlm.nih.gov/pubmed/35207221
http://dx.doi.org/10.3390/jcm11040949
_version_ 1784658013334798336
author Ávila-Gómez, Paulo
Pérez-Mato, María
Hervella, Pablo
Dopico-López, Antonio
da Silva-Candal, Andrés
Bugallo-Casal, Ana
López-Amoedo, Sonia
Candamo-Lourido, María
Sobrino, Tomás
Iglesias-Rey, Ramón
Castillo, José
Campos, Francisco
author_facet Ávila-Gómez, Paulo
Pérez-Mato, María
Hervella, Pablo
Dopico-López, Antonio
da Silva-Candal, Andrés
Bugallo-Casal, Ana
López-Amoedo, Sonia
Candamo-Lourido, María
Sobrino, Tomás
Iglesias-Rey, Ramón
Castillo, José
Campos, Francisco
author_sort Ávila-Gómez, Paulo
collection PubMed
description Background: RNA-binding motif protein 3 (RBM3) is a cold-induced marker of good functional outcome of ischemic stroke that is promising as a protective target. Fibroblast growth factor 21 (FGF21) is an obesity- and temperature-related hormone that upregulates the expression of RBM3, which is beneficial as a recombinant treatment and has been tested under different experimental pathological conditions, including stroke. However, the interaction between RBM3 and FGF21 has not yet been tested for clinical stroke conditions. Methods: In a sample of 66 stroke patients, we analyzed the associations between the FGF21 and RBM3 serum concentrations on admission and at 72 h, body weight, maximum temperature during the first 24 h, and the outcome of patients at 3 months. We also analyzed their association with biomarkers of obesity (adiponectin and leptin) and inflammation (interleukin-6 (IL-6) and interleukin (IL-10)). Results: Higher concentrations of FGF21 on admission and RBM3 at 72 h were associated with good outcomes. Serum FGF21 and RBM3 were directly related to body mass index and inversely related to the maximum temperature during the first 24 h. We found a positive association between the FGF21 concentrations in obese patients with leptin and a negative correlation with adiponectin in non-obese participants. Conclusions: This clinical study demonstrates the association between RBM3 and FGF21 levels and the outcome of stroke patients. Although further investigations are required, these data support the pharmacological induction of RBM3 as a promising protective therapy.
format Online
Article
Text
id pubmed-8875775
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88757752022-02-26 Associations between RNA-Binding Motif Protein 3, Fibroblast Growth Factor 21, and Clinical Outcome in Patients with Stroke Ávila-Gómez, Paulo Pérez-Mato, María Hervella, Pablo Dopico-López, Antonio da Silva-Candal, Andrés Bugallo-Casal, Ana López-Amoedo, Sonia Candamo-Lourido, María Sobrino, Tomás Iglesias-Rey, Ramón Castillo, José Campos, Francisco J Clin Med Article Background: RNA-binding motif protein 3 (RBM3) is a cold-induced marker of good functional outcome of ischemic stroke that is promising as a protective target. Fibroblast growth factor 21 (FGF21) is an obesity- and temperature-related hormone that upregulates the expression of RBM3, which is beneficial as a recombinant treatment and has been tested under different experimental pathological conditions, including stroke. However, the interaction between RBM3 and FGF21 has not yet been tested for clinical stroke conditions. Methods: In a sample of 66 stroke patients, we analyzed the associations between the FGF21 and RBM3 serum concentrations on admission and at 72 h, body weight, maximum temperature during the first 24 h, and the outcome of patients at 3 months. We also analyzed their association with biomarkers of obesity (adiponectin and leptin) and inflammation (interleukin-6 (IL-6) and interleukin (IL-10)). Results: Higher concentrations of FGF21 on admission and RBM3 at 72 h were associated with good outcomes. Serum FGF21 and RBM3 were directly related to body mass index and inversely related to the maximum temperature during the first 24 h. We found a positive association between the FGF21 concentrations in obese patients with leptin and a negative correlation with adiponectin in non-obese participants. Conclusions: This clinical study demonstrates the association between RBM3 and FGF21 levels and the outcome of stroke patients. Although further investigations are required, these data support the pharmacological induction of RBM3 as a promising protective therapy. MDPI 2022-02-11 /pmc/articles/PMC8875775/ /pubmed/35207221 http://dx.doi.org/10.3390/jcm11040949 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ávila-Gómez, Paulo
Pérez-Mato, María
Hervella, Pablo
Dopico-López, Antonio
da Silva-Candal, Andrés
Bugallo-Casal, Ana
López-Amoedo, Sonia
Candamo-Lourido, María
Sobrino, Tomás
Iglesias-Rey, Ramón
Castillo, José
Campos, Francisco
Associations between RNA-Binding Motif Protein 3, Fibroblast Growth Factor 21, and Clinical Outcome in Patients with Stroke
title Associations between RNA-Binding Motif Protein 3, Fibroblast Growth Factor 21, and Clinical Outcome in Patients with Stroke
title_full Associations between RNA-Binding Motif Protein 3, Fibroblast Growth Factor 21, and Clinical Outcome in Patients with Stroke
title_fullStr Associations between RNA-Binding Motif Protein 3, Fibroblast Growth Factor 21, and Clinical Outcome in Patients with Stroke
title_full_unstemmed Associations between RNA-Binding Motif Protein 3, Fibroblast Growth Factor 21, and Clinical Outcome in Patients with Stroke
title_short Associations between RNA-Binding Motif Protein 3, Fibroblast Growth Factor 21, and Clinical Outcome in Patients with Stroke
title_sort associations between rna-binding motif protein 3, fibroblast growth factor 21, and clinical outcome in patients with stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875775/
https://www.ncbi.nlm.nih.gov/pubmed/35207221
http://dx.doi.org/10.3390/jcm11040949
work_keys_str_mv AT avilagomezpaulo associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT perezmatomaria associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT hervellapablo associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT dopicolopezantonio associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT dasilvacandalandres associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT bugallocasalana associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT lopezamoedosonia associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT candamolouridomaria associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT sobrinotomas associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT iglesiasreyramon associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT castillojose associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke
AT camposfrancisco associationsbetweenrnabindingmotifprotein3fibroblastgrowthfactor21andclinicaloutcomeinpatientswithstroke