Impact of lung block shape on cardiac dose for total body irradiation

Evaluating cardiac dose during total body irradiation (TBI) is of increasing interest. A three-dimensional beam model for TBI was commissioned and lung shielding was simulated in a treatment planning system with the cardiac silhouette partially blocked and unblocked. When blocked, the median heart d...

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Detalles Bibliográficos
Autores principales: Glenn, Mallory C., Wallner, Kent, Luk, Samuel M.H., Ermoian, Ralph, Tseng, Yolanda D., Phillips, Mark, Kim, Minsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875787/
https://www.ncbi.nlm.nih.gov/pubmed/35243029
http://dx.doi.org/10.1016/j.phro.2022.01.004
Descripción
Sumario:Evaluating cardiac dose during total body irradiation (TBI) is of increasing interest. A three-dimensional beam model for TBI was commissioned and lung shielding was simulated in a treatment planning system with the cardiac silhouette partially blocked and unblocked. When blocked, the median heart dose decreased by 6% (IQR = 6%) and the median cardiac V12Gy decreased by 27% (IQR = 17%). The median left anterior descending artery dose decreased 20% (IQR = 12%) for blocked cases. Because using partial heart shielding may result in considerable changes in dose to cardiac structures, TBI protocols should explicitly consider lung block design parameters and their potential effects.

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