Impact of lung block shape on cardiac dose for total body irradiation

Evaluating cardiac dose during total body irradiation (TBI) is of increasing interest. A three-dimensional beam model for TBI was commissioned and lung shielding was simulated in a treatment planning system with the cardiac silhouette partially blocked and unblocked. When blocked, the median heart d...

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Detalles Bibliográficos
Autores principales: Glenn, Mallory C., Wallner, Kent, Luk, Samuel M.H., Ermoian, Ralph, Tseng, Yolanda D., Phillips, Mark, Kim, Minsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875787/
https://www.ncbi.nlm.nih.gov/pubmed/35243029
http://dx.doi.org/10.1016/j.phro.2022.01.004
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author Glenn, Mallory C.
Wallner, Kent
Luk, Samuel M.H.
Ermoian, Ralph
Tseng, Yolanda D.
Phillips, Mark
Kim, Minsun
author_facet Glenn, Mallory C.
Wallner, Kent
Luk, Samuel M.H.
Ermoian, Ralph
Tseng, Yolanda D.
Phillips, Mark
Kim, Minsun
author_sort Glenn, Mallory C.
collection PubMed
description Evaluating cardiac dose during total body irradiation (TBI) is of increasing interest. A three-dimensional beam model for TBI was commissioned and lung shielding was simulated in a treatment planning system with the cardiac silhouette partially blocked and unblocked. When blocked, the median heart dose decreased by 6% (IQR = 6%) and the median cardiac V12Gy decreased by 27% (IQR = 17%). The median left anterior descending artery dose decreased 20% (IQR = 12%) for blocked cases. Because using partial heart shielding may result in considerable changes in dose to cardiac structures, TBI protocols should explicitly consider lung block design parameters and their potential effects.
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spelling pubmed-88757872022-03-02 Impact of lung block shape on cardiac dose for total body irradiation Glenn, Mallory C. Wallner, Kent Luk, Samuel M.H. Ermoian, Ralph Tseng, Yolanda D. Phillips, Mark Kim, Minsun Phys Imaging Radiat Oncol Technical Note Evaluating cardiac dose during total body irradiation (TBI) is of increasing interest. A three-dimensional beam model for TBI was commissioned and lung shielding was simulated in a treatment planning system with the cardiac silhouette partially blocked and unblocked. When blocked, the median heart dose decreased by 6% (IQR = 6%) and the median cardiac V12Gy decreased by 27% (IQR = 17%). The median left anterior descending artery dose decreased 20% (IQR = 12%) for blocked cases. Because using partial heart shielding may result in considerable changes in dose to cardiac structures, TBI protocols should explicitly consider lung block design parameters and their potential effects. Elsevier 2022-02-10 /pmc/articles/PMC8875787/ /pubmed/35243029 http://dx.doi.org/10.1016/j.phro.2022.01.004 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Technical Note
Glenn, Mallory C.
Wallner, Kent
Luk, Samuel M.H.
Ermoian, Ralph
Tseng, Yolanda D.
Phillips, Mark
Kim, Minsun
Impact of lung block shape on cardiac dose for total body irradiation
title Impact of lung block shape on cardiac dose for total body irradiation
title_full Impact of lung block shape on cardiac dose for total body irradiation
title_fullStr Impact of lung block shape on cardiac dose for total body irradiation
title_full_unstemmed Impact of lung block shape on cardiac dose for total body irradiation
title_short Impact of lung block shape on cardiac dose for total body irradiation
title_sort impact of lung block shape on cardiac dose for total body irradiation
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875787/
https://www.ncbi.nlm.nih.gov/pubmed/35243029
http://dx.doi.org/10.1016/j.phro.2022.01.004
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