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Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2
The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been veri...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875863/ https://www.ncbi.nlm.nih.gov/pubmed/35216011 http://dx.doi.org/10.3390/v14020418 |
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author | Clayton, Emily Ackerley, Jacob Aelmans, Marianne Ali, Noor Ashcroft, Zoe Ashton, Clara Barker, Robert Budryte, Vakare Burrows, Callum Cai, Shanshan Callaghan, Alex Carberry, Jake Chatwin, Rebecca Davies, Isabella Farlow, Chloe Gamblin, Samuel Iacobut, Aida Lambe, Adam Lynch, Francesca Mihalache, Diana Mokbel, Amani Potamsetty, Santosh Qadir, Zara Soden, Jack Sun, Xiaohan Vasile, Alexandru Wheeler, Otto Rohaim, Mohammed A. Munir, Muhammad |
author_facet | Clayton, Emily Ackerley, Jacob Aelmans, Marianne Ali, Noor Ashcroft, Zoe Ashton, Clara Barker, Robert Budryte, Vakare Burrows, Callum Cai, Shanshan Callaghan, Alex Carberry, Jake Chatwin, Rebecca Davies, Isabella Farlow, Chloe Gamblin, Samuel Iacobut, Aida Lambe, Adam Lynch, Francesca Mihalache, Diana Mokbel, Amani Potamsetty, Santosh Qadir, Zara Soden, Jack Sun, Xiaohan Vasile, Alexandru Wheeler, Otto Rohaim, Mohammed A. Munir, Muhammad |
author_sort | Clayton, Emily |
collection | PubMed |
description | The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19. |
format | Online Article Text |
id | pubmed-8875863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88758632022-02-26 Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2 Clayton, Emily Ackerley, Jacob Aelmans, Marianne Ali, Noor Ashcroft, Zoe Ashton, Clara Barker, Robert Budryte, Vakare Burrows, Callum Cai, Shanshan Callaghan, Alex Carberry, Jake Chatwin, Rebecca Davies, Isabella Farlow, Chloe Gamblin, Samuel Iacobut, Aida Lambe, Adam Lynch, Francesca Mihalache, Diana Mokbel, Amani Potamsetty, Santosh Qadir, Zara Soden, Jack Sun, Xiaohan Vasile, Alexandru Wheeler, Otto Rohaim, Mohammed A. Munir, Muhammad Viruses Review The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19. MDPI 2022-02-17 /pmc/articles/PMC8875863/ /pubmed/35216011 http://dx.doi.org/10.3390/v14020418 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Clayton, Emily Ackerley, Jacob Aelmans, Marianne Ali, Noor Ashcroft, Zoe Ashton, Clara Barker, Robert Budryte, Vakare Burrows, Callum Cai, Shanshan Callaghan, Alex Carberry, Jake Chatwin, Rebecca Davies, Isabella Farlow, Chloe Gamblin, Samuel Iacobut, Aida Lambe, Adam Lynch, Francesca Mihalache, Diana Mokbel, Amani Potamsetty, Santosh Qadir, Zara Soden, Jack Sun, Xiaohan Vasile, Alexandru Wheeler, Otto Rohaim, Mohammed A. Munir, Muhammad Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2 |
title | Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2 |
title_full | Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2 |
title_fullStr | Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2 |
title_full_unstemmed | Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2 |
title_short | Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2 |
title_sort | structural bases of zoonotic and zooanthroponotic transmission of sars-cov-2 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875863/ https://www.ncbi.nlm.nih.gov/pubmed/35216011 http://dx.doi.org/10.3390/v14020418 |
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