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Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2

The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been veri...

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Autores principales: Clayton, Emily, Ackerley, Jacob, Aelmans, Marianne, Ali, Noor, Ashcroft, Zoe, Ashton, Clara, Barker, Robert, Budryte, Vakare, Burrows, Callum, Cai, Shanshan, Callaghan, Alex, Carberry, Jake, Chatwin, Rebecca, Davies, Isabella, Farlow, Chloe, Gamblin, Samuel, Iacobut, Aida, Lambe, Adam, Lynch, Francesca, Mihalache, Diana, Mokbel, Amani, Potamsetty, Santosh, Qadir, Zara, Soden, Jack, Sun, Xiaohan, Vasile, Alexandru, Wheeler, Otto, Rohaim, Mohammed A., Munir, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875863/
https://www.ncbi.nlm.nih.gov/pubmed/35216011
http://dx.doi.org/10.3390/v14020418
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author Clayton, Emily
Ackerley, Jacob
Aelmans, Marianne
Ali, Noor
Ashcroft, Zoe
Ashton, Clara
Barker, Robert
Budryte, Vakare
Burrows, Callum
Cai, Shanshan
Callaghan, Alex
Carberry, Jake
Chatwin, Rebecca
Davies, Isabella
Farlow, Chloe
Gamblin, Samuel
Iacobut, Aida
Lambe, Adam
Lynch, Francesca
Mihalache, Diana
Mokbel, Amani
Potamsetty, Santosh
Qadir, Zara
Soden, Jack
Sun, Xiaohan
Vasile, Alexandru
Wheeler, Otto
Rohaim, Mohammed A.
Munir, Muhammad
author_facet Clayton, Emily
Ackerley, Jacob
Aelmans, Marianne
Ali, Noor
Ashcroft, Zoe
Ashton, Clara
Barker, Robert
Budryte, Vakare
Burrows, Callum
Cai, Shanshan
Callaghan, Alex
Carberry, Jake
Chatwin, Rebecca
Davies, Isabella
Farlow, Chloe
Gamblin, Samuel
Iacobut, Aida
Lambe, Adam
Lynch, Francesca
Mihalache, Diana
Mokbel, Amani
Potamsetty, Santosh
Qadir, Zara
Soden, Jack
Sun, Xiaohan
Vasile, Alexandru
Wheeler, Otto
Rohaim, Mohammed A.
Munir, Muhammad
author_sort Clayton, Emily
collection PubMed
description The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19.
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spelling pubmed-88758632022-02-26 Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2 Clayton, Emily Ackerley, Jacob Aelmans, Marianne Ali, Noor Ashcroft, Zoe Ashton, Clara Barker, Robert Budryte, Vakare Burrows, Callum Cai, Shanshan Callaghan, Alex Carberry, Jake Chatwin, Rebecca Davies, Isabella Farlow, Chloe Gamblin, Samuel Iacobut, Aida Lambe, Adam Lynch, Francesca Mihalache, Diana Mokbel, Amani Potamsetty, Santosh Qadir, Zara Soden, Jack Sun, Xiaohan Vasile, Alexandru Wheeler, Otto Rohaim, Mohammed A. Munir, Muhammad Viruses Review The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19. MDPI 2022-02-17 /pmc/articles/PMC8875863/ /pubmed/35216011 http://dx.doi.org/10.3390/v14020418 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Clayton, Emily
Ackerley, Jacob
Aelmans, Marianne
Ali, Noor
Ashcroft, Zoe
Ashton, Clara
Barker, Robert
Budryte, Vakare
Burrows, Callum
Cai, Shanshan
Callaghan, Alex
Carberry, Jake
Chatwin, Rebecca
Davies, Isabella
Farlow, Chloe
Gamblin, Samuel
Iacobut, Aida
Lambe, Adam
Lynch, Francesca
Mihalache, Diana
Mokbel, Amani
Potamsetty, Santosh
Qadir, Zara
Soden, Jack
Sun, Xiaohan
Vasile, Alexandru
Wheeler, Otto
Rohaim, Mohammed A.
Munir, Muhammad
Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2
title Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2
title_full Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2
title_fullStr Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2
title_full_unstemmed Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2
title_short Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2
title_sort structural bases of zoonotic and zooanthroponotic transmission of sars-cov-2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875863/
https://www.ncbi.nlm.nih.gov/pubmed/35216011
http://dx.doi.org/10.3390/v14020418
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