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Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey
Healthcare workers (HCWs), as frontliners, are assumed to be among the highest risk groups for COVID-19 infection, especially HCWs directly involved in patient care. However, the data on the COVID-19 infection and seroprevalence rates are limited in HCWs. Therefore, we aimed to evaluate the seroprev...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875971/ https://www.ncbi.nlm.nih.gov/pubmed/35214715 http://dx.doi.org/10.3390/vaccines10020258 |
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author | Sonmezer, Meliha Cagla Erul, Enes Sahin, Taha Koray Rudvan Al, Ipek Cosgun, Yasemin Korukluoglu, Gulay Zengin, Humeyra Telli Dizman, Gülçin Inkaya, Ahmet Cagkan Unal, Serhat |
author_facet | Sonmezer, Meliha Cagla Erul, Enes Sahin, Taha Koray Rudvan Al, Ipek Cosgun, Yasemin Korukluoglu, Gulay Zengin, Humeyra Telli Dizman, Gülçin Inkaya, Ahmet Cagkan Unal, Serhat |
author_sort | Sonmezer, Meliha Cagla |
collection | PubMed |
description | Healthcare workers (HCWs), as frontliners, are assumed to be among the highest risk groups for COVID-19 infection, especially HCWs directly involved in patient care. However, the data on the COVID-19 infection and seroprevalence rates are limited in HCWs. Therefore, we aimed to evaluate the seroprevalence rates in HCWs according to risk groups for COVID-19 contraction in a large cross-sectional study from a tertiary care hospital in Turkey. We enrolled 1974 HCWs before the vaccination programs. In two separate semi-quantitative ELISAs, either IgA or IgG antibodies against SARS-CoV-2 spike protein subunit 1 (S1) were measured. The proportion of positive test results for IgG, IgA, or both against SARS-CoV-2 of study subjects was 19% (375/1974). Frontline HCWs who had contact with patients (21.7%, RR 2.1 [1.51–2.92]) and HCWs in working in the COVID-19 units, intensive care units, or emergency department (19.7%, RR 1.61 [1.12–2.32]) had a notably higher Anti-SARS-CoV-2 IgG compared to the rest of HCWs who has no daily patient contacts ([11.1%]; p < 0.0001). HCWs who care for regular patients in the medium-risk group have also experienced a sustained higher risk of exposure to SARS-CoV-2. We should enhance the precaution against COVID-19 to protect HCW’s safety through challenging times. |
format | Online Article Text |
id | pubmed-8875971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88759712022-02-26 Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey Sonmezer, Meliha Cagla Erul, Enes Sahin, Taha Koray Rudvan Al, Ipek Cosgun, Yasemin Korukluoglu, Gulay Zengin, Humeyra Telli Dizman, Gülçin Inkaya, Ahmet Cagkan Unal, Serhat Vaccines (Basel) Article Healthcare workers (HCWs), as frontliners, are assumed to be among the highest risk groups for COVID-19 infection, especially HCWs directly involved in patient care. However, the data on the COVID-19 infection and seroprevalence rates are limited in HCWs. Therefore, we aimed to evaluate the seroprevalence rates in HCWs according to risk groups for COVID-19 contraction in a large cross-sectional study from a tertiary care hospital in Turkey. We enrolled 1974 HCWs before the vaccination programs. In two separate semi-quantitative ELISAs, either IgA or IgG antibodies against SARS-CoV-2 spike protein subunit 1 (S1) were measured. The proportion of positive test results for IgG, IgA, or both against SARS-CoV-2 of study subjects was 19% (375/1974). Frontline HCWs who had contact with patients (21.7%, RR 2.1 [1.51–2.92]) and HCWs in working in the COVID-19 units, intensive care units, or emergency department (19.7%, RR 1.61 [1.12–2.32]) had a notably higher Anti-SARS-CoV-2 IgG compared to the rest of HCWs who has no daily patient contacts ([11.1%]; p < 0.0001). HCWs who care for regular patients in the medium-risk group have also experienced a sustained higher risk of exposure to SARS-CoV-2. We should enhance the precaution against COVID-19 to protect HCW’s safety through challenging times. MDPI 2022-02-08 /pmc/articles/PMC8875971/ /pubmed/35214715 http://dx.doi.org/10.3390/vaccines10020258 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sonmezer, Meliha Cagla Erul, Enes Sahin, Taha Koray Rudvan Al, Ipek Cosgun, Yasemin Korukluoglu, Gulay Zengin, Humeyra Telli Dizman, Gülçin Inkaya, Ahmet Cagkan Unal, Serhat Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey |
title | Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey |
title_full | Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey |
title_fullStr | Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey |
title_full_unstemmed | Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey |
title_short | Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey |
title_sort | seroprevalence of sars-cov-2 antibodies and associated factors in healthcare workers before the era of vaccination at a tertiary care hospital in turkey |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875971/ https://www.ncbi.nlm.nih.gov/pubmed/35214715 http://dx.doi.org/10.3390/vaccines10020258 |
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