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Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey

Healthcare workers (HCWs), as frontliners, are assumed to be among the highest risk groups for COVID-19 infection, especially HCWs directly involved in patient care. However, the data on the COVID-19 infection and seroprevalence rates are limited in HCWs. Therefore, we aimed to evaluate the seroprev...

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Autores principales: Sonmezer, Meliha Cagla, Erul, Enes, Sahin, Taha Koray, Rudvan Al, Ipek, Cosgun, Yasemin, Korukluoglu, Gulay, Zengin, Humeyra, Telli Dizman, Gülçin, Inkaya, Ahmet Cagkan, Unal, Serhat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875971/
https://www.ncbi.nlm.nih.gov/pubmed/35214715
http://dx.doi.org/10.3390/vaccines10020258
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author Sonmezer, Meliha Cagla
Erul, Enes
Sahin, Taha Koray
Rudvan Al, Ipek
Cosgun, Yasemin
Korukluoglu, Gulay
Zengin, Humeyra
Telli Dizman, Gülçin
Inkaya, Ahmet Cagkan
Unal, Serhat
author_facet Sonmezer, Meliha Cagla
Erul, Enes
Sahin, Taha Koray
Rudvan Al, Ipek
Cosgun, Yasemin
Korukluoglu, Gulay
Zengin, Humeyra
Telli Dizman, Gülçin
Inkaya, Ahmet Cagkan
Unal, Serhat
author_sort Sonmezer, Meliha Cagla
collection PubMed
description Healthcare workers (HCWs), as frontliners, are assumed to be among the highest risk groups for COVID-19 infection, especially HCWs directly involved in patient care. However, the data on the COVID-19 infection and seroprevalence rates are limited in HCWs. Therefore, we aimed to evaluate the seroprevalence rates in HCWs according to risk groups for COVID-19 contraction in a large cross-sectional study from a tertiary care hospital in Turkey. We enrolled 1974 HCWs before the vaccination programs. In two separate semi-quantitative ELISAs, either IgA or IgG antibodies against SARS-CoV-2 spike protein subunit 1 (S1) were measured. The proportion of positive test results for IgG, IgA, or both against SARS-CoV-2 of study subjects was 19% (375/1974). Frontline HCWs who had contact with patients (21.7%, RR 2.1 [1.51–2.92]) and HCWs in working in the COVID-19 units, intensive care units, or emergency department (19.7%, RR 1.61 [1.12–2.32]) had a notably higher Anti-SARS-CoV-2 IgG compared to the rest of HCWs who has no daily patient contacts ([11.1%]; p < 0.0001). HCWs who care for regular patients in the medium-risk group have also experienced a sustained higher risk of exposure to SARS-CoV-2. We should enhance the precaution against COVID-19 to protect HCW’s safety through challenging times.
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spelling pubmed-88759712022-02-26 Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey Sonmezer, Meliha Cagla Erul, Enes Sahin, Taha Koray Rudvan Al, Ipek Cosgun, Yasemin Korukluoglu, Gulay Zengin, Humeyra Telli Dizman, Gülçin Inkaya, Ahmet Cagkan Unal, Serhat Vaccines (Basel) Article Healthcare workers (HCWs), as frontliners, are assumed to be among the highest risk groups for COVID-19 infection, especially HCWs directly involved in patient care. However, the data on the COVID-19 infection and seroprevalence rates are limited in HCWs. Therefore, we aimed to evaluate the seroprevalence rates in HCWs according to risk groups for COVID-19 contraction in a large cross-sectional study from a tertiary care hospital in Turkey. We enrolled 1974 HCWs before the vaccination programs. In two separate semi-quantitative ELISAs, either IgA or IgG antibodies against SARS-CoV-2 spike protein subunit 1 (S1) were measured. The proportion of positive test results for IgG, IgA, or both against SARS-CoV-2 of study subjects was 19% (375/1974). Frontline HCWs who had contact with patients (21.7%, RR 2.1 [1.51–2.92]) and HCWs in working in the COVID-19 units, intensive care units, or emergency department (19.7%, RR 1.61 [1.12–2.32]) had a notably higher Anti-SARS-CoV-2 IgG compared to the rest of HCWs who has no daily patient contacts ([11.1%]; p < 0.0001). HCWs who care for regular patients in the medium-risk group have also experienced a sustained higher risk of exposure to SARS-CoV-2. We should enhance the precaution against COVID-19 to protect HCW’s safety through challenging times. MDPI 2022-02-08 /pmc/articles/PMC8875971/ /pubmed/35214715 http://dx.doi.org/10.3390/vaccines10020258 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sonmezer, Meliha Cagla
Erul, Enes
Sahin, Taha Koray
Rudvan Al, Ipek
Cosgun, Yasemin
Korukluoglu, Gulay
Zengin, Humeyra
Telli Dizman, Gülçin
Inkaya, Ahmet Cagkan
Unal, Serhat
Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey
title Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey
title_full Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey
title_fullStr Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey
title_full_unstemmed Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey
title_short Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey
title_sort seroprevalence of sars-cov-2 antibodies and associated factors in healthcare workers before the era of vaccination at a tertiary care hospital in turkey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875971/
https://www.ncbi.nlm.nih.gov/pubmed/35214715
http://dx.doi.org/10.3390/vaccines10020258
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