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Recent Advancements in Tracking Bacterial Effector Protein Translocation

Bacteria-host interactions are characterized by the delivery of bacterial virulence factors, i.e., effectors, into host cells where they counteract host immunity and exploit host responses allowing bacterial survival and spreading. These effectors are translocated into host cells by means of dedicat...

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Detalles Bibliográficos
Autores principales: Braet, Julie, Catteeuw, Dominiek, Van Damme, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876096/
https://www.ncbi.nlm.nih.gov/pubmed/35208715
http://dx.doi.org/10.3390/microorganisms10020260
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author Braet, Julie
Catteeuw, Dominiek
Van Damme, Petra
author_facet Braet, Julie
Catteeuw, Dominiek
Van Damme, Petra
author_sort Braet, Julie
collection PubMed
description Bacteria-host interactions are characterized by the delivery of bacterial virulence factors, i.e., effectors, into host cells where they counteract host immunity and exploit host responses allowing bacterial survival and spreading. These effectors are translocated into host cells by means of dedicated secretion systems such as the type 3 secretion system (T3SS). A comprehensive understanding of effector translocation in a spatio-temporal manner is of critical importance to gain insights into an effector’s mode of action. Various approaches have been developed to understand timing and order of effector translocation, quantities of translocated effectors and their subcellular localization upon translocation into host cells. Recently, the existing toolset has been expanded by newly developed state-of-the art methods to monitor bacterial effector translocation and dynamics. In this review, we elaborate on reported methods and discuss recent advances and shortcomings in this area of tracking bacterial effector translocation.
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spelling pubmed-88760962022-02-26 Recent Advancements in Tracking Bacterial Effector Protein Translocation Braet, Julie Catteeuw, Dominiek Van Damme, Petra Microorganisms Review Bacteria-host interactions are characterized by the delivery of bacterial virulence factors, i.e., effectors, into host cells where they counteract host immunity and exploit host responses allowing bacterial survival and spreading. These effectors are translocated into host cells by means of dedicated secretion systems such as the type 3 secretion system (T3SS). A comprehensive understanding of effector translocation in a spatio-temporal manner is of critical importance to gain insights into an effector’s mode of action. Various approaches have been developed to understand timing and order of effector translocation, quantities of translocated effectors and their subcellular localization upon translocation into host cells. Recently, the existing toolset has been expanded by newly developed state-of-the art methods to monitor bacterial effector translocation and dynamics. In this review, we elaborate on reported methods and discuss recent advances and shortcomings in this area of tracking bacterial effector translocation. MDPI 2022-01-24 /pmc/articles/PMC8876096/ /pubmed/35208715 http://dx.doi.org/10.3390/microorganisms10020260 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Braet, Julie
Catteeuw, Dominiek
Van Damme, Petra
Recent Advancements in Tracking Bacterial Effector Protein Translocation
title Recent Advancements in Tracking Bacterial Effector Protein Translocation
title_full Recent Advancements in Tracking Bacterial Effector Protein Translocation
title_fullStr Recent Advancements in Tracking Bacterial Effector Protein Translocation
title_full_unstemmed Recent Advancements in Tracking Bacterial Effector Protein Translocation
title_short Recent Advancements in Tracking Bacterial Effector Protein Translocation
title_sort recent advancements in tracking bacterial effector protein translocation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876096/
https://www.ncbi.nlm.nih.gov/pubmed/35208715
http://dx.doi.org/10.3390/microorganisms10020260
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