Cargando…
Recent Advancements in Tracking Bacterial Effector Protein Translocation
Bacteria-host interactions are characterized by the delivery of bacterial virulence factors, i.e., effectors, into host cells where they counteract host immunity and exploit host responses allowing bacterial survival and spreading. These effectors are translocated into host cells by means of dedicat...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876096/ https://www.ncbi.nlm.nih.gov/pubmed/35208715 http://dx.doi.org/10.3390/microorganisms10020260 |
_version_ | 1784658086927007744 |
---|---|
author | Braet, Julie Catteeuw, Dominiek Van Damme, Petra |
author_facet | Braet, Julie Catteeuw, Dominiek Van Damme, Petra |
author_sort | Braet, Julie |
collection | PubMed |
description | Bacteria-host interactions are characterized by the delivery of bacterial virulence factors, i.e., effectors, into host cells where they counteract host immunity and exploit host responses allowing bacterial survival and spreading. These effectors are translocated into host cells by means of dedicated secretion systems such as the type 3 secretion system (T3SS). A comprehensive understanding of effector translocation in a spatio-temporal manner is of critical importance to gain insights into an effector’s mode of action. Various approaches have been developed to understand timing and order of effector translocation, quantities of translocated effectors and their subcellular localization upon translocation into host cells. Recently, the existing toolset has been expanded by newly developed state-of-the art methods to monitor bacterial effector translocation and dynamics. In this review, we elaborate on reported methods and discuss recent advances and shortcomings in this area of tracking bacterial effector translocation. |
format | Online Article Text |
id | pubmed-8876096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88760962022-02-26 Recent Advancements in Tracking Bacterial Effector Protein Translocation Braet, Julie Catteeuw, Dominiek Van Damme, Petra Microorganisms Review Bacteria-host interactions are characterized by the delivery of bacterial virulence factors, i.e., effectors, into host cells where they counteract host immunity and exploit host responses allowing bacterial survival and spreading. These effectors are translocated into host cells by means of dedicated secretion systems such as the type 3 secretion system (T3SS). A comprehensive understanding of effector translocation in a spatio-temporal manner is of critical importance to gain insights into an effector’s mode of action. Various approaches have been developed to understand timing and order of effector translocation, quantities of translocated effectors and their subcellular localization upon translocation into host cells. Recently, the existing toolset has been expanded by newly developed state-of-the art methods to monitor bacterial effector translocation and dynamics. In this review, we elaborate on reported methods and discuss recent advances and shortcomings in this area of tracking bacterial effector translocation. MDPI 2022-01-24 /pmc/articles/PMC8876096/ /pubmed/35208715 http://dx.doi.org/10.3390/microorganisms10020260 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Braet, Julie Catteeuw, Dominiek Van Damme, Petra Recent Advancements in Tracking Bacterial Effector Protein Translocation |
title | Recent Advancements in Tracking Bacterial Effector Protein Translocation |
title_full | Recent Advancements in Tracking Bacterial Effector Protein Translocation |
title_fullStr | Recent Advancements in Tracking Bacterial Effector Protein Translocation |
title_full_unstemmed | Recent Advancements in Tracking Bacterial Effector Protein Translocation |
title_short | Recent Advancements in Tracking Bacterial Effector Protein Translocation |
title_sort | recent advancements in tracking bacterial effector protein translocation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876096/ https://www.ncbi.nlm.nih.gov/pubmed/35208715 http://dx.doi.org/10.3390/microorganisms10020260 |
work_keys_str_mv | AT braetjulie recentadvancementsintrackingbacterialeffectorproteintranslocation AT catteeuwdominiek recentadvancementsintrackingbacterialeffectorproteintranslocation AT vandammepetra recentadvancementsintrackingbacterialeffectorproteintranslocation |