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Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory

Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluenc...

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Autores principales: Tissot, Sophie, Gérard, Anne-Lise, Boutry, Justine, Dujon, Antoine M., Russel, Tracey, Siddle, Hannah, Tasiemski, Aurélie, Meliani, Jordan, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata, Thomas, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876101/
https://www.ncbi.nlm.nih.gov/pubmed/35215185
http://dx.doi.org/10.3390/pathogens11020241
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author Tissot, Sophie
Gérard, Anne-Lise
Boutry, Justine
Dujon, Antoine M.
Russel, Tracey
Siddle, Hannah
Tasiemski, Aurélie
Meliani, Jordan
Hamede, Rodrigo
Roche, Benjamin
Ujvari, Beata
Thomas, Frédéric
author_facet Tissot, Sophie
Gérard, Anne-Lise
Boutry, Justine
Dujon, Antoine M.
Russel, Tracey
Siddle, Hannah
Tasiemski, Aurélie
Meliani, Jordan
Hamede, Rodrigo
Roche, Benjamin
Ujvari, Beata
Thomas, Frédéric
author_sort Tissot, Sophie
collection PubMed
description Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluence of tumor and host traits is required for their emergence. This explanation is plausible as transmissible cancers, like all emerging pathogens, will need specific biotic and abiotic conditions to be able to not only emerge, but to spread to detectable levels. Because those conditions would be rarely met, transmissible cancers would rarely spread, and thus most of the time disappear, even though they would regularly appear. Thus, further research is needed to identify the most important factors that can facilitate or block the emergence of transmissible cancers and influence their evolution. Such investigations are particularly relevant given that human activities are increasingly encroaching into wild areas, altering ecosystems and their processes, which can influence the conditions needed for the emergence and spread of transmissible cell lines.
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spelling pubmed-88761012022-02-26 Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory Tissot, Sophie Gérard, Anne-Lise Boutry, Justine Dujon, Antoine M. Russel, Tracey Siddle, Hannah Tasiemski, Aurélie Meliani, Jordan Hamede, Rodrigo Roche, Benjamin Ujvari, Beata Thomas, Frédéric Pathogens Perspective Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluence of tumor and host traits is required for their emergence. This explanation is plausible as transmissible cancers, like all emerging pathogens, will need specific biotic and abiotic conditions to be able to not only emerge, but to spread to detectable levels. Because those conditions would be rarely met, transmissible cancers would rarely spread, and thus most of the time disappear, even though they would regularly appear. Thus, further research is needed to identify the most important factors that can facilitate or block the emergence of transmissible cancers and influence their evolution. Such investigations are particularly relevant given that human activities are increasingly encroaching into wild areas, altering ecosystems and their processes, which can influence the conditions needed for the emergence and spread of transmissible cell lines. MDPI 2022-02-12 /pmc/articles/PMC8876101/ /pubmed/35215185 http://dx.doi.org/10.3390/pathogens11020241 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Tissot, Sophie
Gérard, Anne-Lise
Boutry, Justine
Dujon, Antoine M.
Russel, Tracey
Siddle, Hannah
Tasiemski, Aurélie
Meliani, Jordan
Hamede, Rodrigo
Roche, Benjamin
Ujvari, Beata
Thomas, Frédéric
Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory
title Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory
title_full Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory
title_fullStr Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory
title_full_unstemmed Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory
title_short Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory
title_sort transmissible cancer evolution: the under-estimated role of environmental factors in the “perfect storm” theory
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876101/
https://www.ncbi.nlm.nih.gov/pubmed/35215185
http://dx.doi.org/10.3390/pathogens11020241
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