Cargando…
Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory
Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluenc...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876101/ https://www.ncbi.nlm.nih.gov/pubmed/35215185 http://dx.doi.org/10.3390/pathogens11020241 |
_version_ | 1784658088130772992 |
---|---|
author | Tissot, Sophie Gérard, Anne-Lise Boutry, Justine Dujon, Antoine M. Russel, Tracey Siddle, Hannah Tasiemski, Aurélie Meliani, Jordan Hamede, Rodrigo Roche, Benjamin Ujvari, Beata Thomas, Frédéric |
author_facet | Tissot, Sophie Gérard, Anne-Lise Boutry, Justine Dujon, Antoine M. Russel, Tracey Siddle, Hannah Tasiemski, Aurélie Meliani, Jordan Hamede, Rodrigo Roche, Benjamin Ujvari, Beata Thomas, Frédéric |
author_sort | Tissot, Sophie |
collection | PubMed |
description | Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluence of tumor and host traits is required for their emergence. This explanation is plausible as transmissible cancers, like all emerging pathogens, will need specific biotic and abiotic conditions to be able to not only emerge, but to spread to detectable levels. Because those conditions would be rarely met, transmissible cancers would rarely spread, and thus most of the time disappear, even though they would regularly appear. Thus, further research is needed to identify the most important factors that can facilitate or block the emergence of transmissible cancers and influence their evolution. Such investigations are particularly relevant given that human activities are increasingly encroaching into wild areas, altering ecosystems and their processes, which can influence the conditions needed for the emergence and spread of transmissible cell lines. |
format | Online Article Text |
id | pubmed-8876101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88761012022-02-26 Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory Tissot, Sophie Gérard, Anne-Lise Boutry, Justine Dujon, Antoine M. Russel, Tracey Siddle, Hannah Tasiemski, Aurélie Meliani, Jordan Hamede, Rodrigo Roche, Benjamin Ujvari, Beata Thomas, Frédéric Pathogens Perspective Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluence of tumor and host traits is required for their emergence. This explanation is plausible as transmissible cancers, like all emerging pathogens, will need specific biotic and abiotic conditions to be able to not only emerge, but to spread to detectable levels. Because those conditions would be rarely met, transmissible cancers would rarely spread, and thus most of the time disappear, even though they would regularly appear. Thus, further research is needed to identify the most important factors that can facilitate or block the emergence of transmissible cancers and influence their evolution. Such investigations are particularly relevant given that human activities are increasingly encroaching into wild areas, altering ecosystems and their processes, which can influence the conditions needed for the emergence and spread of transmissible cell lines. MDPI 2022-02-12 /pmc/articles/PMC8876101/ /pubmed/35215185 http://dx.doi.org/10.3390/pathogens11020241 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Tissot, Sophie Gérard, Anne-Lise Boutry, Justine Dujon, Antoine M. Russel, Tracey Siddle, Hannah Tasiemski, Aurélie Meliani, Jordan Hamede, Rodrigo Roche, Benjamin Ujvari, Beata Thomas, Frédéric Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
title | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
title_full | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
title_fullStr | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
title_full_unstemmed | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
title_short | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
title_sort | transmissible cancer evolution: the under-estimated role of environmental factors in the “perfect storm” theory |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876101/ https://www.ncbi.nlm.nih.gov/pubmed/35215185 http://dx.doi.org/10.3390/pathogens11020241 |
work_keys_str_mv | AT tissotsophie transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT gerardannelise transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT boutryjustine transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT dujonantoinem transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT russeltracey transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT siddlehannah transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT tasiemskiaurelie transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT melianijordan transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT hamederodrigo transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT rochebenjamin transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT ujvaribeata transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory AT thomasfrederic transmissiblecancerevolutiontheunderestimatedroleofenvironmentalfactorsintheperfectstormtheory |