Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines

A large number of different types of cancer have been shown to be associated with an abnormal metabolism of phosphatidylcholine (PC), the main component of eukaryotic cell membranes. Indeed, the overexpression of choline kinase α1 (ChoKα1), the enzyme that catalyses the bioconversion of choline to p...

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Detalles Bibliográficos
Autores principales: García-Molina, Pablo, Sola-Leyva, Alberto, Luque-Navarro, Pilar M., Laso, Alejandro, Ríos-Marco, Pablo, Ríos, Antonio, Lanari, Daniela, Torretta, Archimede, Parisini, Emilio, López-Cara, Luisa C., Marco, Carmen, Carrasco-Jiménez, María P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876215/
https://www.ncbi.nlm.nih.gov/pubmed/35214160
http://dx.doi.org/10.3390/pharmaceutics14020426

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