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NanoSIMS Imaging Reveals the Impact of Ligand-ASO Conjugate Stability on ASO Subcellular Distribution

The delivery of antisense oligonucleotides (ASOs) to specific cell types via targeted endocytosis is challenging due to the low cell surface expression of target receptors and inefficient escape of ASOs from the endosomal pathway. Conjugating ASOs to glucagon-like peptide 1 (GLP1) leads to efficient...

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Detalles Bibliográficos
Autores principales:	Kay, Emma, Stulz, Rouven, Becquart, Cécile, Lovric, Jelena, Tängemo, Carolina, Thomen, Aurélien, Baždarević, Dženita, Najafinobar, Neda, Dahlén, Anders, Pielach, Anna, Fernandez-Rodriguez, Julia, Strömberg, Roger, Ämmälä, Carina, Andersson, Shalini, Kurczy, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876276/ https://www.ncbi.nlm.nih.gov/pubmed/35214195 http://dx.doi.org/10.3390/pharmaceutics14020463

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