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Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors
A series of anionic homopolymers, poly(sodium 2-(acrylamido)-2-methyl-1-propanesulfonate) (PAMPS) and amphiphilic copolymers of AMPS and sodium 11-(acrylamido)undecanoate (AaU), both block (PAMPS(75)-b-PAaU(n)), and random (P(AMPS(m)-co-AaU(n))), were synthesized and their antiviral activity against...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876367/ https://www.ncbi.nlm.nih.gov/pubmed/35214042 http://dx.doi.org/10.3390/pharmaceutics14020309 |
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author | Botwina, Pawel Obłoza, Magdalena Zatorska-Płachta, Maria Kamiński, Kamil Mizusaki, Masanobu Yusa, Shin-Ichi Szczubiałka, Krzysztof Pyrc, Krzysztof Nowakowska, Maria |
author_facet | Botwina, Pawel Obłoza, Magdalena Zatorska-Płachta, Maria Kamiński, Kamil Mizusaki, Masanobu Yusa, Shin-Ichi Szczubiałka, Krzysztof Pyrc, Krzysztof Nowakowska, Maria |
author_sort | Botwina, Pawel |
collection | PubMed |
description | A series of anionic homopolymers, poly(sodium 2-(acrylamido)-2-methyl-1-propanesulfonate) (PAMPS) and amphiphilic copolymers of AMPS and sodium 11-(acrylamido)undecanoate (AaU), both block (PAMPS(75)-b-PAaU(n)), and random (P(AMPS(m)-co-AaU(n))), were synthesized and their antiviral activity against Zika virus (ZIKV) was evaluated. Interestingly, while the homopolymers showed limited antiviral activity, the copolymers are very efficient antivirals. This observation was explained considering that under the conditions relevant to the biological experiments (pH 7.4 PBS buffer) the macromolecules of these copolymers exist as negatively charged (zeta potential about −25 mV) nanoparticles (4–12 nm) due to their self-organization. They inhibit the ZIKV replication cycle by binding to the cell surface and thereby blocking virus attachment to host cells. Considering good solubility in aqueous media, low toxicity, and high selectivity index (SI) of the PAMPS-b-PAaU copolymers, they can be considered promising agents against ZIKV infections. |
format | Online Article Text |
id | pubmed-8876367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88763672022-02-26 Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors Botwina, Pawel Obłoza, Magdalena Zatorska-Płachta, Maria Kamiński, Kamil Mizusaki, Masanobu Yusa, Shin-Ichi Szczubiałka, Krzysztof Pyrc, Krzysztof Nowakowska, Maria Pharmaceutics Article A series of anionic homopolymers, poly(sodium 2-(acrylamido)-2-methyl-1-propanesulfonate) (PAMPS) and amphiphilic copolymers of AMPS and sodium 11-(acrylamido)undecanoate (AaU), both block (PAMPS(75)-b-PAaU(n)), and random (P(AMPS(m)-co-AaU(n))), were synthesized and their antiviral activity against Zika virus (ZIKV) was evaluated. Interestingly, while the homopolymers showed limited antiviral activity, the copolymers are very efficient antivirals. This observation was explained considering that under the conditions relevant to the biological experiments (pH 7.4 PBS buffer) the macromolecules of these copolymers exist as negatively charged (zeta potential about −25 mV) nanoparticles (4–12 nm) due to their self-organization. They inhibit the ZIKV replication cycle by binding to the cell surface and thereby blocking virus attachment to host cells. Considering good solubility in aqueous media, low toxicity, and high selectivity index (SI) of the PAMPS-b-PAaU copolymers, they can be considered promising agents against ZIKV infections. MDPI 2022-01-27 /pmc/articles/PMC8876367/ /pubmed/35214042 http://dx.doi.org/10.3390/pharmaceutics14020309 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Botwina, Pawel Obłoza, Magdalena Zatorska-Płachta, Maria Kamiński, Kamil Mizusaki, Masanobu Yusa, Shin-Ichi Szczubiałka, Krzysztof Pyrc, Krzysztof Nowakowska, Maria Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
title | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
title_full | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
title_fullStr | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
title_full_unstemmed | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
title_short | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
title_sort | self-organized nanoparticles of random and block copolymers of sodium 2-(acrylamido)-2-methyl-1-propanesulfonate and sodium 11-(acrylamido)undecanoate as safe and effective zika virus inhibitors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876367/ https://www.ncbi.nlm.nih.gov/pubmed/35214042 http://dx.doi.org/10.3390/pharmaceutics14020309 |
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