An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease

Encephalopathy, delirium, and agitation are documented symptoms of coronavirus disease (COVID-19) infection, but research into the management of agitation in the setting of COVID-19 and pre-existing neuropsychiatric disease is ongoing. We present a 55-year-old male patient with early-onset Alzheimer...

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Autores principales: Sykora, Daniel, Stonnington, Cynthia M., Jain, Neeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876388/
https://www.ncbi.nlm.nih.gov/pubmed/33973880
http://dx.doi.org/10.1097/WAD.0000000000000456
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author Sykora, Daniel
Stonnington, Cynthia M.
Jain, Neeta
author_facet Sykora, Daniel
Stonnington, Cynthia M.
Jain, Neeta
author_sort Sykora, Daniel
collection PubMed
description Encephalopathy, delirium, and agitation are documented symptoms of coronavirus disease (COVID-19) infection, but research into the management of agitation in the setting of COVID-19 and pre-existing neuropsychiatric disease is ongoing. We present a 55-year-old male patient with early-onset Alzheimer disease and deteriorating mental and functional status who presented to our institution with agitation and persistent COVID-19 positivity on polymerase chain reaction testing. His agitation was improved through pharmacologic optimization including the avoidance of benzodiazepines and initiation of clonidine and prazosin, which temporally coincided with the resolution of his nearly 2-month long COVID-19 positivity.
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spelling pubmed-88763882022-03-03 An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease Sykora, Daniel Stonnington, Cynthia M. Jain, Neeta Alzheimer Dis Assoc Disord Brief Reports Encephalopathy, delirium, and agitation are documented symptoms of coronavirus disease (COVID-19) infection, but research into the management of agitation in the setting of COVID-19 and pre-existing neuropsychiatric disease is ongoing. We present a 55-year-old male patient with early-onset Alzheimer disease and deteriorating mental and functional status who presented to our institution with agitation and persistent COVID-19 positivity on polymerase chain reaction testing. His agitation was improved through pharmacologic optimization including the avoidance of benzodiazepines and initiation of clonidine and prazosin, which temporally coincided with the resolution of his nearly 2-month long COVID-19 positivity. Lippincott Williams & Wilkins 2022 2021-05-11 /pmc/articles/PMC8876388/ /pubmed/33973880 http://dx.doi.org/10.1097/WAD.0000000000000456 Text en Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Brief Reports
Sykora, Daniel
Stonnington, Cynthia M.
Jain, Neeta
An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease
title An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease
title_full An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease
title_fullStr An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease
title_full_unstemmed An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease
title_short An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease
title_sort agitated patient with covid-19 infection and early-onset alzheimer disease
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876388/
https://www.ncbi.nlm.nih.gov/pubmed/33973880
http://dx.doi.org/10.1097/WAD.0000000000000456
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