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Distinct antibody profiles in HLA-B(∗)57(+), HLA-B(∗)57(−) HIV controllers and chronic progressors

Spontaneous control of HIV replication without treatment in HIV-1 controllers (HICs) was associated with the development of an efficient T-cell response. In addition, increasing data suggest that the humoral response participates in viral clearance. DESIGN: In-depth characterization of Ab response i...

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Autores principales: Klingler, Jéromine, Paul, Nicodème, Laumond, Géraldine, Schmidt, Sylvie, Mayr, Luzia M., Decoville, Thomas, Lambotte, Olivier, Autran, Brigitte, Bahram, Seiamak, Moog, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876439/
https://www.ncbi.nlm.nih.gov/pubmed/34581307
http://dx.doi.org/10.1097/QAD.0000000000003080
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author Klingler, Jéromine
Paul, Nicodème
Laumond, Géraldine
Schmidt, Sylvie
Mayr, Luzia M.
Decoville, Thomas
Lambotte, Olivier
Autran, Brigitte
Bahram, Seiamak
Moog, Christiane
author_facet Klingler, Jéromine
Paul, Nicodème
Laumond, Géraldine
Schmidt, Sylvie
Mayr, Luzia M.
Decoville, Thomas
Lambotte, Olivier
Autran, Brigitte
Bahram, Seiamak
Moog, Christiane
author_sort Klingler, Jéromine
collection PubMed
description Spontaneous control of HIV replication without treatment in HIV-1 controllers (HICs) was associated with the development of an efficient T-cell response. In addition, increasing data suggest that the humoral response participates in viral clearance. DESIGN: In-depth characterization of Ab response in HICs may help to define new parameters associated with this control. METHODS: We assessed the levels of total and HIV-specific IgA and IgG subtypes induction and their functional potencies – that is, neutralization, phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), according to the individual's major histocompatibility complex class I (HLA)-B∗57 status, and compared it with nontreated chronic progressors. RESULTS: We found that despite an undetectable viral load, HICs displayed HIV-specific IgG levels similar to those of chronic progressors. Interestingly, our compelling multifunctional analysis demonstrates that the functional Ab profile, by itself, allowed to discriminate HLA-B∗57(+) HICs from HLA-B∗57(−) HICs and chronic progressors. CONCLUSION: These results show that HICs display a particular HIV-specific antibody (Ab) profile that may participate in HIV control and emphasize the relevance of multifunctional Ab response analysis in future Ab-driven vaccine studies.
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spelling pubmed-88764392022-03-03 Distinct antibody profiles in HLA-B(∗)57(+), HLA-B(∗)57(−) HIV controllers and chronic progressors Klingler, Jéromine Paul, Nicodème Laumond, Géraldine Schmidt, Sylvie Mayr, Luzia M. Decoville, Thomas Lambotte, Olivier Autran, Brigitte Bahram, Seiamak Moog, Christiane AIDS Basic Science Spontaneous control of HIV replication without treatment in HIV-1 controllers (HICs) was associated with the development of an efficient T-cell response. In addition, increasing data suggest that the humoral response participates in viral clearance. DESIGN: In-depth characterization of Ab response in HICs may help to define new parameters associated with this control. METHODS: We assessed the levels of total and HIV-specific IgA and IgG subtypes induction and their functional potencies – that is, neutralization, phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), according to the individual's major histocompatibility complex class I (HLA)-B∗57 status, and compared it with nontreated chronic progressors. RESULTS: We found that despite an undetectable viral load, HICs displayed HIV-specific IgG levels similar to those of chronic progressors. Interestingly, our compelling multifunctional analysis demonstrates that the functional Ab profile, by itself, allowed to discriminate HLA-B∗57(+) HICs from HLA-B∗57(−) HICs and chronic progressors. CONCLUSION: These results show that HICs display a particular HIV-specific antibody (Ab) profile that may participate in HIV control and emphasize the relevance of multifunctional Ab response analysis in future Ab-driven vaccine studies. Lippincott Williams & Wilkins 2022-03-15 2021-10-01 /pmc/articles/PMC8876439/ /pubmed/34581307 http://dx.doi.org/10.1097/QAD.0000000000003080 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Basic Science
Klingler, Jéromine
Paul, Nicodème
Laumond, Géraldine
Schmidt, Sylvie
Mayr, Luzia M.
Decoville, Thomas
Lambotte, Olivier
Autran, Brigitte
Bahram, Seiamak
Moog, Christiane
Distinct antibody profiles in HLA-B(∗)57(+), HLA-B(∗)57(−) HIV controllers and chronic progressors
title Distinct antibody profiles in HLA-B(∗)57(+), HLA-B(∗)57(−) HIV controllers and chronic progressors
title_full Distinct antibody profiles in HLA-B(∗)57(+), HLA-B(∗)57(−) HIV controllers and chronic progressors
title_fullStr Distinct antibody profiles in HLA-B(∗)57(+), HLA-B(∗)57(−) HIV controllers and chronic progressors
title_full_unstemmed Distinct antibody profiles in HLA-B(∗)57(+), HLA-B(∗)57(−) HIV controllers and chronic progressors
title_short Distinct antibody profiles in HLA-B(∗)57(+), HLA-B(∗)57(−) HIV controllers and chronic progressors
title_sort distinct antibody profiles in hla-b(∗)57(+), hla-b(∗)57(−) hiv controllers and chronic progressors
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876439/
https://www.ncbi.nlm.nih.gov/pubmed/34581307
http://dx.doi.org/10.1097/QAD.0000000000003080
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