Inhibition of ceramide accumulation in AdipoR1(–/–) mice increases photoreceptor survival and improves vision

Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been associated with nonsyndromic and syndromic retinitis pigmentosa. Here, we show that the absence of AdipoR1 in mice leads to progressive p...

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Detalles Bibliográficos
Autores principales: Lewandowski, Dominik, Foik, Andrzej T., Smidak, Roman, Choi, Elliot H., Zhang, Jianye, Hoang, Thanh, Tworak, Aleksander, Suh, Susie, Leinonen, Henri, Dong, Zhiqian, Pinto, Antonio F.M., Tom, Emily, Luu, Jennings, Lee, Joan, Ma, Xiuli, Bieberich, Erhard, Blackshaw, Seth, Saghatelian, Alan, Lyon, David C., Skowronska-Krawczyk, Dorota, Tabaka, Marcin, Palczewski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876453/
https://www.ncbi.nlm.nih.gov/pubmed/35015730
http://dx.doi.org/10.1172/jci.insight.156301

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