A single-domain i-body, AD-114, attenuates renal fibrosis through blockade of CXCR4

The G protein–coupled CXC chemokine receptor 4 (CXCR4) is a candidate therapeutic target for tissue fibrosis. A fully human single-domain antibody-like scaffold i-body AD-114-PA600 (AD-114) with specific high binding affinity to CXCR4 has been developed. To define its renoprotective role, AD-114 was...

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Detalles Bibliográficos
Autores principales: Cao, Qinghua, Huang, Chunling, Yi, Hao, Gill, Anthony J., Chou, Angela, Foley, Michael, Hosking, Chris G., Lim, Kevin K., Triffon, Cristina F., Shi, Ying, Chen, Xin-Ming, Pollock, Carol A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876455/
https://www.ncbi.nlm.nih.gov/pubmed/35015734
http://dx.doi.org/10.1172/jci.insight.143018

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