P. aeruginosa augments irradiation injury via 15-lipoxygenase–catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis

Total body irradiation (TBI) targets sensitive bone marrow hematopoietic cells and gut epithelial cells, causing their death and inducing a state of immunodeficiency combined with intestinal dysbiosis and nonproductive immune responses. We found enhanced Pseudomonas aeruginosa (PAO1) colonization of...

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Detalles Bibliográficos
Autores principales: Dar, Haider H., Epperly, Michael W., Tyurin, Vladimir A., Amoscato, Andrew A., Anthonymuthu, Tamil S., Souryavong, Austin B., Kapralov, Alexander A., Shurin, Galina V., Samovich, Svetlana N., St. Croix, Claudette M., Watkins, Simon C., Wenzel, Sally E., Mallampalli, Rama K., Greenberger, Joel S., Bayır, Hülya, Kagan, Valerian E., Tyurina, Yulia Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876480/
https://www.ncbi.nlm.nih.gov/pubmed/35041620
http://dx.doi.org/10.1172/jci.insight.156013

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