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Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study

Background: This is an investigation of the human papillomavirus (HPV) infection and its correlation with the risk of ectopic pregnancy (EP). Methods: The cohort study includes 11,239 patients with newly diagnosed HPV infections between 2000 and 2012, and by using computer-generated random numbers,...

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Autores principales: Hsu, Li-Chuan, Tu, Ting-Yu, Chen, Hui-Yuan, Chang, Renin, Yip, Hei-Tung, Chou, Mei-Chia, Wei, James Cheng-Chung, Tsui, Kuan-Hao, Sheu, Jim Jinn-Chyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876513/
https://www.ncbi.nlm.nih.gov/pubmed/35207661
http://dx.doi.org/10.3390/jpm12020172
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author Hsu, Li-Chuan
Tu, Ting-Yu
Chen, Hui-Yuan
Chang, Renin
Yip, Hei-Tung
Chou, Mei-Chia
Wei, James Cheng-Chung
Tsui, Kuan-Hao
Sheu, Jim Jinn-Chyuan
author_facet Hsu, Li-Chuan
Tu, Ting-Yu
Chen, Hui-Yuan
Chang, Renin
Yip, Hei-Tung
Chou, Mei-Chia
Wei, James Cheng-Chung
Tsui, Kuan-Hao
Sheu, Jim Jinn-Chyuan
author_sort Hsu, Li-Chuan
collection PubMed
description Background: This is an investigation of the human papillomavirus (HPV) infection and its correlation with the risk of ectopic pregnancy (EP). Methods: The cohort study includes 11,239 patients with newly diagnosed HPV infections between 2000 and 2012, and by using computer-generated random numbers, patients who do not have HPV infections are selected randomly as the comparison cohort. The HPV infection cohort is matched to comparison individuals at a 1:10 ratio by age and index year. All individuals included in the study were followed up to the point they developed EP, pulled-out from the insurance program, lost to follow-up, or until the end of 2013. A Cox proportional-hazards regression analysis was used to analyze the risk of EP with the hazard ratios (HRs) and 95% confidence intervals (CIs) between the HPV and control cohort. Results: The adjusted hazard ratio (aHR) of EP for HPV patients relative to controls is 1.70 (95% CI = 1.04, 2.78), indicating a positive correlation between EP and HPV in the 13-year follow-up period, after adjusting for age and relevant comorbidities. The sensitivity analyses yield similar results. Conclusions: A history of HPV infection is a potential risk factor associated with the development of subsequent EP in Taiwanese individuals, especially those diagnosed with an HPV infection within 3 years.
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spelling pubmed-88765132022-02-26 Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study Hsu, Li-Chuan Tu, Ting-Yu Chen, Hui-Yuan Chang, Renin Yip, Hei-Tung Chou, Mei-Chia Wei, James Cheng-Chung Tsui, Kuan-Hao Sheu, Jim Jinn-Chyuan J Pers Med Article Background: This is an investigation of the human papillomavirus (HPV) infection and its correlation with the risk of ectopic pregnancy (EP). Methods: The cohort study includes 11,239 patients with newly diagnosed HPV infections between 2000 and 2012, and by using computer-generated random numbers, patients who do not have HPV infections are selected randomly as the comparison cohort. The HPV infection cohort is matched to comparison individuals at a 1:10 ratio by age and index year. All individuals included in the study were followed up to the point they developed EP, pulled-out from the insurance program, lost to follow-up, or until the end of 2013. A Cox proportional-hazards regression analysis was used to analyze the risk of EP with the hazard ratios (HRs) and 95% confidence intervals (CIs) between the HPV and control cohort. Results: The adjusted hazard ratio (aHR) of EP for HPV patients relative to controls is 1.70 (95% CI = 1.04, 2.78), indicating a positive correlation between EP and HPV in the 13-year follow-up period, after adjusting for age and relevant comorbidities. The sensitivity analyses yield similar results. Conclusions: A history of HPV infection is a potential risk factor associated with the development of subsequent EP in Taiwanese individuals, especially those diagnosed with an HPV infection within 3 years. MDPI 2022-01-27 /pmc/articles/PMC8876513/ /pubmed/35207661 http://dx.doi.org/10.3390/jpm12020172 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsu, Li-Chuan
Tu, Ting-Yu
Chen, Hui-Yuan
Chang, Renin
Yip, Hei-Tung
Chou, Mei-Chia
Wei, James Cheng-Chung
Tsui, Kuan-Hao
Sheu, Jim Jinn-Chyuan
Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study
title Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study
title_full Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study
title_fullStr Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study
title_full_unstemmed Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study
title_short Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study
title_sort female human papillomavirus infection associated with increased risk of ectopic pregnancy: early evidence from taiwan population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876513/
https://www.ncbi.nlm.nih.gov/pubmed/35207661
http://dx.doi.org/10.3390/jpm12020172
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