Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci

BACKGROUND: Prostate cancer is multifocal with distinct molecular subtypes. The utility of genomic subtyping has been challenged due to inter- and intrafocal heterogeneity. We sought to characterize the subtype-defining molecular alterations of primary prostate cancer across all tumor foci within ra...

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Detalles Bibliográficos
Autores principales: Fontugne, Jacqueline, Cai, Peter Y., Alnajar, Hussein, Bhinder, Bhavneet, Park, Kyung, Ye, Huihui, Beg, Shaham, Sailer, Verena, Siddiqui, Javed, Blattner-Johnson, Mirjam, Croyle, Jaclyn A., Noorzad, Zohal, Calagua, Carla, MacDonald, Theresa Y., Axcrona, Ulrika, Bogaard, Mari, Axcrona, Karol, Scherr, Douglas S., Sanda, Martin G., Johannessen, Bjarne, Chinnaiyan, Arul M., Elemento, Olivier, Skotheim, Rolf I., Rubin, Mark A., Barbieri, Christopher E., Mosquera, Juan Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876549/
https://www.ncbi.nlm.nih.gov/pubmed/35050902
http://dx.doi.org/10.1172/jci.insight.155309

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