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Head-to-Head Comparison of Response Rates to the Two mRNA SARS-CοV-2 Vaccines in a Large Cohort of Solid Organ Transplant (SOT) Recipients

Due to their higher risk of developing life-threatening COVID-19 disease, solid organ transplant (SOT) recipients have been prioritized in the vaccination programs of many countries. However, there is increasing evidence of reduced immunogenicity to SARS-CοV-2 vaccination. The present study investig...

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Autores principales: Marinaki, Smaragdi, Degiannis, Dimitrios, Roussos, Sotirios, Xagas, Efstathios, Tsoutsoura, Paraskevi, Adamopoulos, Stamatis, Sypsa, Vana, Chaidaroglou, Antigoni, Pavlopoulou, Ioanna D., Hatzakis, Angelos, Boletis, Ioannis N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876597/
https://www.ncbi.nlm.nih.gov/pubmed/35214649
http://dx.doi.org/10.3390/vaccines10020190
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author Marinaki, Smaragdi
Degiannis, Dimitrios
Roussos, Sotirios
Xagas, Efstathios
Tsoutsoura, Paraskevi
Adamopoulos, Stamatis
Sypsa, Vana
Chaidaroglou, Antigoni
Pavlopoulou, Ioanna D.
Hatzakis, Angelos
Boletis, Ioannis N.
author_facet Marinaki, Smaragdi
Degiannis, Dimitrios
Roussos, Sotirios
Xagas, Efstathios
Tsoutsoura, Paraskevi
Adamopoulos, Stamatis
Sypsa, Vana
Chaidaroglou, Antigoni
Pavlopoulou, Ioanna D.
Hatzakis, Angelos
Boletis, Ioannis N.
author_sort Marinaki, Smaragdi
collection PubMed
description Due to their higher risk of developing life-threatening COVID-19 disease, solid organ transplant (SOT) recipients have been prioritized in the vaccination programs of many countries. However, there is increasing evidence of reduced immunogenicity to SARS-CοV-2 vaccination. The present study investigated humoral response, safety, and effectiveness after the two mRNA vaccines in 455 SOT recipients. Overall, the antibody response rate was low, at 39.6%. Higher immunogenicity was detected among individuals vaccinated with the mRNA1273 compared to those with the BNT162b2 vaccine (47% vs. 36%, respectively, p = 0.025) as well as higher median antibody levels of 31 (7, 372) (AU/mL) vs. 11 (7, 215) AU/mL, respectively. Among the covariates assessed, vaccination with the BNT162b2 vaccine, antimetabolite- and steroid-containing immunosuppression, female gender, the type of transplanted organ and older age were factors that negatively influenced immune response. Only mild adverse effects were observed. Our findings confirm poor immunogenicity after vaccination, implicating a reevaluation of vaccination policy in SOT recipients.
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spelling pubmed-88765972022-02-26 Head-to-Head Comparison of Response Rates to the Two mRNA SARS-CοV-2 Vaccines in a Large Cohort of Solid Organ Transplant (SOT) Recipients Marinaki, Smaragdi Degiannis, Dimitrios Roussos, Sotirios Xagas, Efstathios Tsoutsoura, Paraskevi Adamopoulos, Stamatis Sypsa, Vana Chaidaroglou, Antigoni Pavlopoulou, Ioanna D. Hatzakis, Angelos Boletis, Ioannis N. Vaccines (Basel) Article Due to their higher risk of developing life-threatening COVID-19 disease, solid organ transplant (SOT) recipients have been prioritized in the vaccination programs of many countries. However, there is increasing evidence of reduced immunogenicity to SARS-CοV-2 vaccination. The present study investigated humoral response, safety, and effectiveness after the two mRNA vaccines in 455 SOT recipients. Overall, the antibody response rate was low, at 39.6%. Higher immunogenicity was detected among individuals vaccinated with the mRNA1273 compared to those with the BNT162b2 vaccine (47% vs. 36%, respectively, p = 0.025) as well as higher median antibody levels of 31 (7, 372) (AU/mL) vs. 11 (7, 215) AU/mL, respectively. Among the covariates assessed, vaccination with the BNT162b2 vaccine, antimetabolite- and steroid-containing immunosuppression, female gender, the type of transplanted organ and older age were factors that negatively influenced immune response. Only mild adverse effects were observed. Our findings confirm poor immunogenicity after vaccination, implicating a reevaluation of vaccination policy in SOT recipients. MDPI 2022-01-25 /pmc/articles/PMC8876597/ /pubmed/35214649 http://dx.doi.org/10.3390/vaccines10020190 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marinaki, Smaragdi
Degiannis, Dimitrios
Roussos, Sotirios
Xagas, Efstathios
Tsoutsoura, Paraskevi
Adamopoulos, Stamatis
Sypsa, Vana
Chaidaroglou, Antigoni
Pavlopoulou, Ioanna D.
Hatzakis, Angelos
Boletis, Ioannis N.
Head-to-Head Comparison of Response Rates to the Two mRNA SARS-CοV-2 Vaccines in a Large Cohort of Solid Organ Transplant (SOT) Recipients
title Head-to-Head Comparison of Response Rates to the Two mRNA SARS-CοV-2 Vaccines in a Large Cohort of Solid Organ Transplant (SOT) Recipients
title_full Head-to-Head Comparison of Response Rates to the Two mRNA SARS-CοV-2 Vaccines in a Large Cohort of Solid Organ Transplant (SOT) Recipients
title_fullStr Head-to-Head Comparison of Response Rates to the Two mRNA SARS-CοV-2 Vaccines in a Large Cohort of Solid Organ Transplant (SOT) Recipients
title_full_unstemmed Head-to-Head Comparison of Response Rates to the Two mRNA SARS-CοV-2 Vaccines in a Large Cohort of Solid Organ Transplant (SOT) Recipients
title_short Head-to-Head Comparison of Response Rates to the Two mRNA SARS-CοV-2 Vaccines in a Large Cohort of Solid Organ Transplant (SOT) Recipients
title_sort head-to-head comparison of response rates to the two mrna sars-cοv-2 vaccines in a large cohort of solid organ transplant (sot) recipients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876597/
https://www.ncbi.nlm.nih.gov/pubmed/35214649
http://dx.doi.org/10.3390/vaccines10020190
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