Cargando…

New Blood Coagulation Factor XIIa Inhibitors: Molecular Modeling, Synthesis, and Experimental Confirmation

In the modern world, complications caused by disorders in the blood coagulation system are found in almost all areas of medicine. Thus, the development of new, more advanced drugs that can prevent pathological conditions without disrupting normal hemostasis is an urgent task. The blood coagulation f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tashchilova, Anna, Podoplelova, Nadezhda, Sulimov, Alexey, Kutov, Danil, Ilin, Ivan, Panteleev, Mikhail, Shikhaliev, Khidmet, Medvedeva, Svetlana, Novichikhina, Nadezhda, Potapov, Andrey, Sulimov, Vladimir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876603/ https://www.ncbi.nlm.nih.gov/pubmed/35209023 http://dx.doi.org/10.3390/molecules27041234

Ejemplares similares

Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-ij]Quinolin-2(1H)-one as New Inhibitors of Factor Xa and Factor XIa
por: Novichikhina, Nadezhda, et al.
Publicado: (2020)

Supercomputer Search for the New Inhibitors of the Coagulation Factor XIIa
por: Sulimov, A. V., et al.
Publicado: (2022)

New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation
por: Novichikhina, Nadezhda P., et al.
Publicado: (2023)

New Chemicals Suppressing SARS-CoV-2 Replication in Cell Culture
por: Sulimov, Alexey, et al.
Publicado: (2022)

Quantum-Chemical Quasi-Docking for Molecular Dynamics Calculations
por: Sulimov, Alexey, et al.
Publicado: (2022)

Novel Inhibitors of 2′-O-Methyltransferase of the SARS-CoV-2 Coronavirus
por: Sulimov, Alexey, et al.
Publicado: (2022)

Application of Molecular Modeling to Development of New Factor Xa Inhibitors
por: Sulimov, Vladimir B., et al.
Publicado: (2015)

New Infestin-4 Mutants with Increased Selectivity against Factor XIIa
por: Kolyadko, Vladimir N., et al.
Publicado: (2015)

New Aspects of the Reaction of Thioacetamide and N-Substituted Maleimides
por: Aseeva, Yulia V., et al.
Publicado: (2022)

Supercomputing, Docking and Quantum Mechanics in Quest for Inhibitors of Papain-like Protease of SARS-CoV-2
por: Sulimov, A. V., et al.
Publicado: (2021)

Synthesis of 4,5-Dihydro-1H-[1,2]dithiolo[3,4-c]quinoline-1-thione Derivatives and Their Application as Protein Kinase Inhibitors
por: Medvedeva, Svetlana M., et al.
Publicado: (2022)

Platelet Surface-Associated Activation and Secretion-Mediated Inhibition of Coagulation Factor XII
por: Zakharova, Natalia V., et al.
Publicado: (2015)

Evaluation of Docking Target Functions by the Comprehensive Investigation of Protein-Ligand Energy Minima
por: Oferkin, Igor V., et al.
Publicado: (2015)

Fabrication and Characterization of Thin Metal Films Deposited by Electroless Plating with Organic Additives for Electrical Circuits Applications
por: Buylov, Nikita S., et al.
Publicado: (2023)

Evaluation of the novel algorithm of flexible ligand docking with moveable target-protein atoms
por: Sulimov, Alexey V., et al.
Publicado: (2017)

High-Throughput Docking and Molecular Dynamics Simulations towards the Identification of Potential Inhibitors against Human Coagulation Factor XIIa
por: Xu, Dongfang, et al.
Publicado: (2020)

6-Hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline Alleviates Oxidative Stress and NF-κB-Mediated Inflammation in Rats with Experimental Parkinson’s Disease
por: Kryl’skii, Evgenii D., et al.
Publicado: (2023)

A novel synthetic approach to hydroimidazo[1,5-b]pyridazines by the recyclization of itaconimides and HPLC–HRMS monitoring of the reaction pathway
por: Vandyshev, Dmitry Yu, et al.
Publicado: (2017)

The Coagulation Factor XIIa Inhibitor rHA-Infestin-4 Improves Outcome after Cerebral Ischemia/Reperfusion Injury in Rats
por: Krupka, Jennifer, et al.
Publicado: (2016)

6-Hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline Demonstrates Anti-Inflammatory Properties and Reduces Oxidative Stress in Acetaminophen-Induced Liver Injury in Rats
por: Kryl’skii, Evgenii D., et al.
Publicado: (2023)

A Study of the Peculiarities of the Formation of a Hybrid Interface Based on Polydopamine between Dental Tissues and Dental Composites, Using IR and Raman Microspectroscopy, at the Submicron Level
por: Seredin, Pavel, et al.
Publicado: (2023)

Recyclization of Maleimides by Binucleophiles as a General Approach for Building Hydrogenated Heterocyclic Systems
por: Vandyshev, Dmitriy Yu., et al.
Publicado: (2022)

Novel SLFN14 mutation associated with macrothrombocytopenia in a patient with severe haemorrhagic syndrome
por: Polokhov, Dmitrii, et al.
Publicado: (2023)

Combined Docking with Classical Force Field and Quantum Chemical Semiempirical Method PM7
por: Sulimov, A. V., et al.
Publicado: (2017)

Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors
por: Platte, Simon, et al.
Publicado: (2021)

The new antioxidant 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline has a protective effect against carbon tetrachloride-induced hepatic injury in rats
por: Kryl'skii, Evgenii Dmitrievich, et al.
Publicado: (2022)

A Multifield Study on Dimethyl Acetylenedicarboxylate: A Reagent Able to Build a New Cycle on Diaminoimidazoles
por: Vandyshev, Dmitrii Yu., et al.
Publicado: (2022)

Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa
por: Hopp, Sarah, et al.
Publicado: (2017)

Pharmacological Inhibition of Factor XIIa Attenuates Abdominal Aortic Aneurysm, Reduces Atherosclerosis, and Stabilizes Atherosclerotic Plaques
por: Searle, Amy K., et al.
Publicado: (2021)

Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa
por: Shibeko, Alexey M, et al.
Publicado: (2010)

A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters
por: Shikhaliev, Khidmet, et al.
Publicado: (2017)

Asymmetrical Forces Dictate the Distribution and Morphology of Platelets in Blood Clots
por: Kovalenko, Tatiana A., et al.
Publicado: (2021)

Lundep, a Sand Fly Salivary Endonuclease Increases Leishmania Parasite Survival in Neutrophils and Inhibits XIIa Contact Activation in Human Plasma
por: Chagas, Andrezza C., et al.
Publicado: (2014)

The effects of two types of renin-angiotensin system inhibitors on the hypertension induced by new pressor protein associated with beta-factor XIIa in rats
por: Pejhan, Akbar, et al.
Publicado: (2020)

Platelet functional abnormalities in pediatric patients with kaposiform hemangioendothelioma/Kasabach-Merritt phenomenon
por: Martyanov, Alexey A., et al.
Publicado: (2023)

miR-204-5p in vivo inhibition cause diminished CD45RO cells rate in lungs of melanoma B16-bearing mice
por: Palkina, Nadezhda, et al.
Publicado: (2022)

Regulation of Complement and Contact System Activation via C1 Inhibitor Potentiation and Factor XIIa Activity Modulation by Sulfated Glycans – Structure-Activity Relationships
por: Schoenfeld, Ann-Kathrin, et al.
Publicado: (2016)

Molecular Genetic Analysis of Russian Patients with Coagulation Factor FVII Deficiency
por: Pshenichnikova, Olesya, et al.
Publicado: (2023)

Interactions Outside the Proteinase-binding Loop Contribute Significantly to the Inhibition of Activated Coagulation Factor XII by Its Canonical Inhibitor from Corn
por: Korneeva, Vera A., et al.
Publicado: (2014)

Patient-Specific Modelling of Blood Coagulation
por: Ratto, N., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i5ve4mvb35es4vbf875nh681hm