Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids

The alkaloid tazopsine 1 was introduced in the late 2000s as a novel antiplasmodial hit compound active against Plasmodium falciparum hepatic stages, with the potential to develop prophylactic drugs based on this novel chemical scaffold. However, the structural determinants of tazopsine 1 bioactivit...

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Detalles Bibliográficos
Autores principales: Keita, Antoinette, Franetich, Jean-François, Carraz, Maëlle, Valentin, Loïse, Bordessoules, Mallaury, Baron, Ludivine, Bigeard, Pierre, Dupuy, Florian, Geay, Valentine, Tefit, Maurel, Sarrasin, Véronique, Michel, Sylvie, Lavazec, Catherine, Houzé, Sandrine, Mazier, Dominique, Soulard, Valérie, Porée, François-Hugues, Duval, Romain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876632/
https://www.ncbi.nlm.nih.gov/pubmed/35214104
http://dx.doi.org/10.3390/pharmaceutics14020372

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