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Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear

The plasmatic von Willebrand factor (VWF) circulates in a compact form unable to bind platelets. Upon shear stress, the VWF A1 domain is exposed, allowing VWF-binding to platelet glycoprotein Ib-V-IX (GPIbα chain). For a better understanding of the role of this interaction in cardiovascular disease,...

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Detalles Bibliográficos
Autores principales:	Hrdinova, Johana, Fernández, Delia I., Ercig, Bogac, Tullemans, Bibian M. E., Suylen, Dennis P. L., Agten, Stijn M., Jurk, Kerstin, Hackeng, Tilman M., Vanhoorelbeke, Karen, Voorberg, Jan, Reutelingsperger, Chris P. M., Wichapong, Kanin, Heemskerk, Johan W. M., Nicolaes, Gerry A. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876638/ https://www.ncbi.nlm.nih.gov/pubmed/35216161 http://dx.doi.org/10.3390/ijms23042046

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