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Biliary Atresia in 2021: Epidemiology, Screening and Public Policy

Biliary atresia (BA) is a rare newborn liver disease with significant morbidity and mortality, especially if not recognized and treated early in life. It is the most common cause of liver-related death in children and the leading indication for liver transplantation in the pediatric population. Time...

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Autores principales: Schreiber, Richard A., Harpavat, Sanjiv, Hulscher, Jan B. F., Wildhaber, Barbara E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876662/
https://www.ncbi.nlm.nih.gov/pubmed/35207269
http://dx.doi.org/10.3390/jcm11040999
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author Schreiber, Richard A.
Harpavat, Sanjiv
Hulscher, Jan B. F.
Wildhaber, Barbara E.
author_facet Schreiber, Richard A.
Harpavat, Sanjiv
Hulscher, Jan B. F.
Wildhaber, Barbara E.
author_sort Schreiber, Richard A.
collection PubMed
description Biliary atresia (BA) is a rare newborn liver disease with significant morbidity and mortality, especially if not recognized and treated early in life. It is the most common cause of liver-related death in children and the leading indication for liver transplantation in the pediatric population. Timely intervention with a Kasai portoenterostomy (KPE) can significantly improve prognosis. Delayed disease recognition, late patient referral, and untimely surgery remains a worldwide problem. This article will focus on biliary atresia from a global public health perspective, including disease epidemiology, current national screening programs, and their impact on outcome, as well as new and novel BA screening initiatives. Policy challenges for the implementation of BA screening programs will also be discussed, highlighting examples from the North American, European, and Asian experience.
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spelling pubmed-88766622022-02-26 Biliary Atresia in 2021: Epidemiology, Screening and Public Policy Schreiber, Richard A. Harpavat, Sanjiv Hulscher, Jan B. F. Wildhaber, Barbara E. J Clin Med Article Biliary atresia (BA) is a rare newborn liver disease with significant morbidity and mortality, especially if not recognized and treated early in life. It is the most common cause of liver-related death in children and the leading indication for liver transplantation in the pediatric population. Timely intervention with a Kasai portoenterostomy (KPE) can significantly improve prognosis. Delayed disease recognition, late patient referral, and untimely surgery remains a worldwide problem. This article will focus on biliary atresia from a global public health perspective, including disease epidemiology, current national screening programs, and their impact on outcome, as well as new and novel BA screening initiatives. Policy challenges for the implementation of BA screening programs will also be discussed, highlighting examples from the North American, European, and Asian experience. MDPI 2022-02-14 /pmc/articles/PMC8876662/ /pubmed/35207269 http://dx.doi.org/10.3390/jcm11040999 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schreiber, Richard A.
Harpavat, Sanjiv
Hulscher, Jan B. F.
Wildhaber, Barbara E.
Biliary Atresia in 2021: Epidemiology, Screening and Public Policy
title Biliary Atresia in 2021: Epidemiology, Screening and Public Policy
title_full Biliary Atresia in 2021: Epidemiology, Screening and Public Policy
title_fullStr Biliary Atresia in 2021: Epidemiology, Screening and Public Policy
title_full_unstemmed Biliary Atresia in 2021: Epidemiology, Screening and Public Policy
title_short Biliary Atresia in 2021: Epidemiology, Screening and Public Policy
title_sort biliary atresia in 2021: epidemiology, screening and public policy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876662/
https://www.ncbi.nlm.nih.gov/pubmed/35207269
http://dx.doi.org/10.3390/jcm11040999
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