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Therapeutic Applications of Programmable DNA Nanostructures
Deoxyribonucleic acid (DNA) nanotechnology, a frontier in biomedical engineering, is an emerging field that has enabled the engineering of molecular-scale DNA materials with applications in biomedicine such as bioimaging, biodetection, and drug delivery over the past decades. The programmability of...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876680/ https://www.ncbi.nlm.nih.gov/pubmed/35208439 http://dx.doi.org/10.3390/mi13020315 |
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author | Aye, Seaim Lwin Sato, Yusuke |
author_facet | Aye, Seaim Lwin Sato, Yusuke |
author_sort | Aye, Seaim Lwin |
collection | PubMed |
description | Deoxyribonucleic acid (DNA) nanotechnology, a frontier in biomedical engineering, is an emerging field that has enabled the engineering of molecular-scale DNA materials with applications in biomedicine such as bioimaging, biodetection, and drug delivery over the past decades. The programmability of DNA nanostructures allows the precise engineering of DNA nanocarriers with controllable shapes, sizes, surface chemistries, and functions to deliver therapeutic and functional payloads to target cells with higher efficiency and enhanced specificity. Programmability and control over design also allow the creation of dynamic devices, such as DNA nanorobots, that can react to external stimuli and execute programmed tasks. This review focuses on the current findings and progress in the field, mainly on the employment of DNA nanostructures such as DNA origami nanorobots, DNA nanotubes, DNA tetrahedra, DNA boxes, and DNA nanoflowers in the biomedical field for therapeutic purposes. We will also discuss the fate of DNA nanostructures in living cells, the major obstacles to overcome, that is, the stability of DNA nanostructures in biomedical applications, and the opportunities for DNA nanostructure-based drug delivery in the future. |
format | Online Article Text |
id | pubmed-8876680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88766802022-02-26 Therapeutic Applications of Programmable DNA Nanostructures Aye, Seaim Lwin Sato, Yusuke Micromachines (Basel) Review Deoxyribonucleic acid (DNA) nanotechnology, a frontier in biomedical engineering, is an emerging field that has enabled the engineering of molecular-scale DNA materials with applications in biomedicine such as bioimaging, biodetection, and drug delivery over the past decades. The programmability of DNA nanostructures allows the precise engineering of DNA nanocarriers with controllable shapes, sizes, surface chemistries, and functions to deliver therapeutic and functional payloads to target cells with higher efficiency and enhanced specificity. Programmability and control over design also allow the creation of dynamic devices, such as DNA nanorobots, that can react to external stimuli and execute programmed tasks. This review focuses on the current findings and progress in the field, mainly on the employment of DNA nanostructures such as DNA origami nanorobots, DNA nanotubes, DNA tetrahedra, DNA boxes, and DNA nanoflowers in the biomedical field for therapeutic purposes. We will also discuss the fate of DNA nanostructures in living cells, the major obstacles to overcome, that is, the stability of DNA nanostructures in biomedical applications, and the opportunities for DNA nanostructure-based drug delivery in the future. MDPI 2022-02-17 /pmc/articles/PMC8876680/ /pubmed/35208439 http://dx.doi.org/10.3390/mi13020315 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Aye, Seaim Lwin Sato, Yusuke Therapeutic Applications of Programmable DNA Nanostructures |
title | Therapeutic Applications of Programmable DNA Nanostructures |
title_full | Therapeutic Applications of Programmable DNA Nanostructures |
title_fullStr | Therapeutic Applications of Programmable DNA Nanostructures |
title_full_unstemmed | Therapeutic Applications of Programmable DNA Nanostructures |
title_short | Therapeutic Applications of Programmable DNA Nanostructures |
title_sort | therapeutic applications of programmable dna nanostructures |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876680/ https://www.ncbi.nlm.nih.gov/pubmed/35208439 http://dx.doi.org/10.3390/mi13020315 |
work_keys_str_mv | AT ayeseaimlwin therapeuticapplicationsofprogrammablednananostructures AT satoyusuke therapeuticapplicationsofprogrammablednananostructures |