Cargando…

Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures

Despite the enormous progress and development of modern therapies, lung cancer remains one of the most common causes of death among men and women. The key element in the development of new anti-cancer drugs is proper planning of the preclinical research phase. The most adequate basic research exempl...

Descripción completa

Detalles Bibliográficos
Autores principales: Wieleba, Irena, Wojas-Krawczyk, Kamila, Krawczyk, Paweł, Milanowski, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876687/
https://www.ncbi.nlm.nih.gov/pubmed/35216378
http://dx.doi.org/10.3390/ijms23042261
_version_ 1784658232609865728
author Wieleba, Irena
Wojas-Krawczyk, Kamila
Krawczyk, Paweł
Milanowski, Janusz
author_facet Wieleba, Irena
Wojas-Krawczyk, Kamila
Krawczyk, Paweł
Milanowski, Janusz
author_sort Wieleba, Irena
collection PubMed
description Despite the enormous progress and development of modern therapies, lung cancer remains one of the most common causes of death among men and women. The key element in the development of new anti-cancer drugs is proper planning of the preclinical research phase. The most adequate basic research exemplary for cancer study are 3D tumor microenvironment in vitro models, which allow us to avoid the use of animal models and ensure replicable culture condition. However, the question tormenting the scientist is how to choose the best tool for tumor microenvironment research, especially for extremely heterogenous lung cancer cases. In the presented review we are focused to explain the key factors of lung cancer biology, its microenvironment, and clinical gaps related to different therapies. The review summarized the most important strategies for in vitro culture models mimicking the tumor–tumor microenvironmental interaction, as well as all advantages and disadvantages were depicted. This knowledge could facilitate the right decision to designate proper pre-clinical in vitro study, based on available analytical tools and technical capabilities, to obtain more reliable and personalized results for faster introduction them into the future clinical trials.
format Online
Article
Text
id pubmed-8876687
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88766872022-02-26 Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures Wieleba, Irena Wojas-Krawczyk, Kamila Krawczyk, Paweł Milanowski, Janusz Int J Mol Sci Review Despite the enormous progress and development of modern therapies, lung cancer remains one of the most common causes of death among men and women. The key element in the development of new anti-cancer drugs is proper planning of the preclinical research phase. The most adequate basic research exemplary for cancer study are 3D tumor microenvironment in vitro models, which allow us to avoid the use of animal models and ensure replicable culture condition. However, the question tormenting the scientist is how to choose the best tool for tumor microenvironment research, especially for extremely heterogenous lung cancer cases. In the presented review we are focused to explain the key factors of lung cancer biology, its microenvironment, and clinical gaps related to different therapies. The review summarized the most important strategies for in vitro culture models mimicking the tumor–tumor microenvironmental interaction, as well as all advantages and disadvantages were depicted. This knowledge could facilitate the right decision to designate proper pre-clinical in vitro study, based on available analytical tools and technical capabilities, to obtain more reliable and personalized results for faster introduction them into the future clinical trials. MDPI 2022-02-18 /pmc/articles/PMC8876687/ /pubmed/35216378 http://dx.doi.org/10.3390/ijms23042261 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wieleba, Irena
Wojas-Krawczyk, Kamila
Krawczyk, Paweł
Milanowski, Janusz
Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures
title Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures
title_full Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures
title_fullStr Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures
title_full_unstemmed Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures
title_short Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures
title_sort clinical application perspectives of lung cancers 3d tumor microenvironment models for in vitro cultures
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876687/
https://www.ncbi.nlm.nih.gov/pubmed/35216378
http://dx.doi.org/10.3390/ijms23042261
work_keys_str_mv AT wielebairena clinicalapplicationperspectivesoflungcancers3dtumormicroenvironmentmodelsforinvitrocultures
AT wojaskrawczykkamila clinicalapplicationperspectivesoflungcancers3dtumormicroenvironmentmodelsforinvitrocultures
AT krawczykpaweł clinicalapplicationperspectivesoflungcancers3dtumormicroenvironmentmodelsforinvitrocultures
AT milanowskijanusz clinicalapplicationperspectivesoflungcancers3dtumormicroenvironmentmodelsforinvitrocultures