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Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures
Despite the enormous progress and development of modern therapies, lung cancer remains one of the most common causes of death among men and women. The key element in the development of new anti-cancer drugs is proper planning of the preclinical research phase. The most adequate basic research exempl...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876687/ https://www.ncbi.nlm.nih.gov/pubmed/35216378 http://dx.doi.org/10.3390/ijms23042261 |
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author | Wieleba, Irena Wojas-Krawczyk, Kamila Krawczyk, Paweł Milanowski, Janusz |
author_facet | Wieleba, Irena Wojas-Krawczyk, Kamila Krawczyk, Paweł Milanowski, Janusz |
author_sort | Wieleba, Irena |
collection | PubMed |
description | Despite the enormous progress and development of modern therapies, lung cancer remains one of the most common causes of death among men and women. The key element in the development of new anti-cancer drugs is proper planning of the preclinical research phase. The most adequate basic research exemplary for cancer study are 3D tumor microenvironment in vitro models, which allow us to avoid the use of animal models and ensure replicable culture condition. However, the question tormenting the scientist is how to choose the best tool for tumor microenvironment research, especially for extremely heterogenous lung cancer cases. In the presented review we are focused to explain the key factors of lung cancer biology, its microenvironment, and clinical gaps related to different therapies. The review summarized the most important strategies for in vitro culture models mimicking the tumor–tumor microenvironmental interaction, as well as all advantages and disadvantages were depicted. This knowledge could facilitate the right decision to designate proper pre-clinical in vitro study, based on available analytical tools and technical capabilities, to obtain more reliable and personalized results for faster introduction them into the future clinical trials. |
format | Online Article Text |
id | pubmed-8876687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88766872022-02-26 Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures Wieleba, Irena Wojas-Krawczyk, Kamila Krawczyk, Paweł Milanowski, Janusz Int J Mol Sci Review Despite the enormous progress and development of modern therapies, lung cancer remains one of the most common causes of death among men and women. The key element in the development of new anti-cancer drugs is proper planning of the preclinical research phase. The most adequate basic research exemplary for cancer study are 3D tumor microenvironment in vitro models, which allow us to avoid the use of animal models and ensure replicable culture condition. However, the question tormenting the scientist is how to choose the best tool for tumor microenvironment research, especially for extremely heterogenous lung cancer cases. In the presented review we are focused to explain the key factors of lung cancer biology, its microenvironment, and clinical gaps related to different therapies. The review summarized the most important strategies for in vitro culture models mimicking the tumor–tumor microenvironmental interaction, as well as all advantages and disadvantages were depicted. This knowledge could facilitate the right decision to designate proper pre-clinical in vitro study, based on available analytical tools and technical capabilities, to obtain more reliable and personalized results for faster introduction them into the future clinical trials. MDPI 2022-02-18 /pmc/articles/PMC8876687/ /pubmed/35216378 http://dx.doi.org/10.3390/ijms23042261 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wieleba, Irena Wojas-Krawczyk, Kamila Krawczyk, Paweł Milanowski, Janusz Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures |
title | Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures |
title_full | Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures |
title_fullStr | Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures |
title_full_unstemmed | Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures |
title_short | Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures |
title_sort | clinical application perspectives of lung cancers 3d tumor microenvironment models for in vitro cultures |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876687/ https://www.ncbi.nlm.nih.gov/pubmed/35216378 http://dx.doi.org/10.3390/ijms23042261 |
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