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Systemic lipid peroxidation profile from patients with breast cancer changes according to the lymph nodal metastasis status

Metastasis is the leading cause of cancer death. Considering that lymph nodes are the major pathway for cancer spreading and that the metastatic process is under oxidative stress effects, this study aims to evaluate the differential lipid peroxidation profile in the blood of breast cancer patients r...

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Detalles Bibliográficos
Autores principales: de Oliveira, Stefania Tagliari, Bessani, Monica Pavaneli, Scandolara, Thalita Basso, Silva, Janaína Carla, Kawassaki, Aedra Carla Bufalo, Fagotti, Pâmella Aparecida Ferreira, Maito, Vitor Teixeira, de Souza, Janoário Athanazio, Rech, Daniel, Panis, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876690/
https://www.ncbi.nlm.nih.gov/pubmed/35233438
http://dx.doi.org/10.18632/oncoscience.550
Descripción
Sumario:Metastasis is the leading cause of cancer death. Considering that lymph nodes are the major pathway for cancer spreading and that the metastatic process is under oxidative stress effects, this study aims to evaluate the differential lipid peroxidation profile in the blood of breast cancer patients regarding their lymph nodal status (LN). A total of 105 women diagnosed with breast cancer were included before chemotherapy started. LN was determined by assessing the histopathological analysis of patients’ biopsies, and groups were categorized according to the presence (LN+, n = 48) or absence (LN−, n = 57) of metastases. Lipid peroxidation profiles (LPO) were determined in blood by high-sensitivity chemiluminescence. After patients’ categorization in groups according to their clinicopathological features, LN− patients aged over 50 years presented significantly lower LPO when compared to those under 50 years. Further, LN− patients carrying HER2 positive tumors presented augmented LPO when compared to patients bearing luminal B or triple-negative tumors. LN+ group also had reduced LPO when presented intratumoral clots. The significant contribution of this study was to show that LPO correlates with specific clinical features of patients with breast cancer according to their LN status and that such profile is significantly affected by the presence of metastases.