A Case of Stevens–Johnson Syndrome Complicated with Multimatrix System Mesalamine in Ulcerative Colitis

A 41-year-old man was treated with prednisolone (PSL) and multimatrix (MMX) mesalamine for remission induction therapy of ulcerative colitis. PSL was tapered due to successful remission induction treatment. During the treatment course, ocular foreign body sensation, eyelid swelling, ocular conjuncti...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanazawa, Mimari, Tominaga, Keiichi, Kanamori, Akira, Tanaka, Takanao, Masuyama, Satoshi, Watanabe, Shoko, Abe, Keiichiro, Yamamiya, Akira, Goda, Kenichi, Irisawa, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876713/
https://www.ncbi.nlm.nih.gov/pubmed/35208599
http://dx.doi.org/10.3390/medicina58020276
_version_ 1784658238997790720
author Kanazawa, Mimari
Tominaga, Keiichi
Kanamori, Akira
Tanaka, Takanao
Masuyama, Satoshi
Watanabe, Shoko
Abe, Keiichiro
Yamamiya, Akira
Goda, Kenichi
Irisawa, Atsushi
author_facet Kanazawa, Mimari
Tominaga, Keiichi
Kanamori, Akira
Tanaka, Takanao
Masuyama, Satoshi
Watanabe, Shoko
Abe, Keiichiro
Yamamiya, Akira
Goda, Kenichi
Irisawa, Atsushi
author_sort Kanazawa, Mimari
collection PubMed
description A 41-year-old man was treated with prednisolone (PSL) and multimatrix (MMX) mesalamine for remission induction therapy of ulcerative colitis. PSL was tapered due to successful remission induction treatment. During the treatment course, ocular foreign body sensation, eyelid swelling, ocular conjunctiva hyperemia, facial redness and swelling, watery nasal discharge, stomatitis, anal pain, and reddish puffiness on the bilateral dorsum of the hands appeared, and he was diagnosed with Stevens–Johnson syndrome (SJS). SJS was improved by PSL treatment and intravenous immunoglobulin. MMX mesalamine was the causative agent by drug-induced lymphocyte stimulation test. This is the first reported case of SJS with MMX mesalamine.
format Online
Article
Text
id pubmed-8876713
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88767132022-02-26 A Case of Stevens–Johnson Syndrome Complicated with Multimatrix System Mesalamine in Ulcerative Colitis Kanazawa, Mimari Tominaga, Keiichi Kanamori, Akira Tanaka, Takanao Masuyama, Satoshi Watanabe, Shoko Abe, Keiichiro Yamamiya, Akira Goda, Kenichi Irisawa, Atsushi Medicina (Kaunas) Case Report A 41-year-old man was treated with prednisolone (PSL) and multimatrix (MMX) mesalamine for remission induction therapy of ulcerative colitis. PSL was tapered due to successful remission induction treatment. During the treatment course, ocular foreign body sensation, eyelid swelling, ocular conjunctiva hyperemia, facial redness and swelling, watery nasal discharge, stomatitis, anal pain, and reddish puffiness on the bilateral dorsum of the hands appeared, and he was diagnosed with Stevens–Johnson syndrome (SJS). SJS was improved by PSL treatment and intravenous immunoglobulin. MMX mesalamine was the causative agent by drug-induced lymphocyte stimulation test. This is the first reported case of SJS with MMX mesalamine. MDPI 2022-02-11 /pmc/articles/PMC8876713/ /pubmed/35208599 http://dx.doi.org/10.3390/medicina58020276 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kanazawa, Mimari
Tominaga, Keiichi
Kanamori, Akira
Tanaka, Takanao
Masuyama, Satoshi
Watanabe, Shoko
Abe, Keiichiro
Yamamiya, Akira
Goda, Kenichi
Irisawa, Atsushi
A Case of Stevens–Johnson Syndrome Complicated with Multimatrix System Mesalamine in Ulcerative Colitis
title A Case of Stevens–Johnson Syndrome Complicated with Multimatrix System Mesalamine in Ulcerative Colitis
title_full A Case of Stevens–Johnson Syndrome Complicated with Multimatrix System Mesalamine in Ulcerative Colitis
title_fullStr A Case of Stevens–Johnson Syndrome Complicated with Multimatrix System Mesalamine in Ulcerative Colitis
title_full_unstemmed A Case of Stevens–Johnson Syndrome Complicated with Multimatrix System Mesalamine in Ulcerative Colitis
title_short A Case of Stevens–Johnson Syndrome Complicated with Multimatrix System Mesalamine in Ulcerative Colitis
title_sort case of stevens–johnson syndrome complicated with multimatrix system mesalamine in ulcerative colitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876713/
https://www.ncbi.nlm.nih.gov/pubmed/35208599
http://dx.doi.org/10.3390/medicina58020276
work_keys_str_mv AT kanazawamimari acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT tominagakeiichi acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT kanamoriakira acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT tanakatakanao acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT masuyamasatoshi acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT watanabeshoko acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT abekeiichiro acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT yamamiyaakira acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT godakenichi acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT irisawaatsushi acaseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT kanazawamimari caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT tominagakeiichi caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT kanamoriakira caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT tanakatakanao caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT masuyamasatoshi caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT watanabeshoko caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT abekeiichiro caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT yamamiyaakira caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT godakenichi caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis
AT irisawaatsushi caseofstevensjohnsonsyndromecomplicatedwithmultimatrixsystemmesalamineinulcerativecolitis

Ejemplares similares