Cargando…
Toxicity of Proton Therapy versus Photon Therapy on Salvage Re-Irradiation for Non-Small Cell Lung Cancer
This study evaluated the toxicity associated with radiation techniques on curative re-irradiation (re-RT) in patients with thoracic recurrence of non-small cell lung cancer (NSCLC). From 2011 to 2019, we retrospectively reviewed the data of 63 patients with salvage re-RT for in-field or marginal rec...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876714/ https://www.ncbi.nlm.nih.gov/pubmed/35207579 http://dx.doi.org/10.3390/life12020292 |
_version_ | 1784658239253643264 |
---|---|
author | Yang, Kyungmi Suh, Yang-Gun Shin, Hyunju Pyo, Hongryull Moon, Sung Ho Ahn, Yong Chan Oh, Dongryul Chung, Eunah Jo, Kwanghyun Noh, Jae Myoung |
author_facet | Yang, Kyungmi Suh, Yang-Gun Shin, Hyunju Pyo, Hongryull Moon, Sung Ho Ahn, Yong Chan Oh, Dongryul Chung, Eunah Jo, Kwanghyun Noh, Jae Myoung |
author_sort | Yang, Kyungmi |
collection | PubMed |
description | This study evaluated the toxicity associated with radiation techniques on curative re-irradiation (re-RT) in patients with thoracic recurrence of non-small cell lung cancer (NSCLC). From 2011 to 2019, we retrospectively reviewed the data of 63 patients with salvage re-RT for in-field or marginal recurrence of NSCLC at two independent institutions. Re-RT techniques using X-ray beams and proton beam therapy (PBT) were also included. Re-RT had a 2-year overall survival (OS) and local progression-free survival of 48.0% and 52.0%, respectively. Fifteen patients experienced grade 3 or higher toxicity after re-RT. The complication rates were 18.2% (4/22) and 26.8% (11/41) in PBT patients and X-ray patients, respectively. Airway or esophageal fistulas occurred in seven patients (11.1%). Fistulas or severe airway obstruction occurred in patients with tumors adjacent to the proximal bronchial tree and esophagus, who underwent hypofractionated radiotherapy (RT) or concurrent chemotherapy, and with a higher dose exposure to the esophagus. In conclusion, salvage re-RT was feasible even in patients with local recurrence within the previous RT field. PBT showed similar survival outcomes and toxicity to those of other techniques. However, thoracic re-RT should be performed carefully considering tumor location and RT regimens such as the fraction size and concurrent chemotherapy. |
format | Online Article Text |
id | pubmed-8876714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88767142022-02-26 Toxicity of Proton Therapy versus Photon Therapy on Salvage Re-Irradiation for Non-Small Cell Lung Cancer Yang, Kyungmi Suh, Yang-Gun Shin, Hyunju Pyo, Hongryull Moon, Sung Ho Ahn, Yong Chan Oh, Dongryul Chung, Eunah Jo, Kwanghyun Noh, Jae Myoung Life (Basel) Article This study evaluated the toxicity associated with radiation techniques on curative re-irradiation (re-RT) in patients with thoracic recurrence of non-small cell lung cancer (NSCLC). From 2011 to 2019, we retrospectively reviewed the data of 63 patients with salvage re-RT for in-field or marginal recurrence of NSCLC at two independent institutions. Re-RT techniques using X-ray beams and proton beam therapy (PBT) were also included. Re-RT had a 2-year overall survival (OS) and local progression-free survival of 48.0% and 52.0%, respectively. Fifteen patients experienced grade 3 or higher toxicity after re-RT. The complication rates were 18.2% (4/22) and 26.8% (11/41) in PBT patients and X-ray patients, respectively. Airway or esophageal fistulas occurred in seven patients (11.1%). Fistulas or severe airway obstruction occurred in patients with tumors adjacent to the proximal bronchial tree and esophagus, who underwent hypofractionated radiotherapy (RT) or concurrent chemotherapy, and with a higher dose exposure to the esophagus. In conclusion, salvage re-RT was feasible even in patients with local recurrence within the previous RT field. PBT showed similar survival outcomes and toxicity to those of other techniques. However, thoracic re-RT should be performed carefully considering tumor location and RT regimens such as the fraction size and concurrent chemotherapy. MDPI 2022-02-16 /pmc/articles/PMC8876714/ /pubmed/35207579 http://dx.doi.org/10.3390/life12020292 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yang, Kyungmi Suh, Yang-Gun Shin, Hyunju Pyo, Hongryull Moon, Sung Ho Ahn, Yong Chan Oh, Dongryul Chung, Eunah Jo, Kwanghyun Noh, Jae Myoung Toxicity of Proton Therapy versus Photon Therapy on Salvage Re-Irradiation for Non-Small Cell Lung Cancer |
title | Toxicity of Proton Therapy versus Photon Therapy on Salvage Re-Irradiation for Non-Small Cell Lung Cancer |
title_full | Toxicity of Proton Therapy versus Photon Therapy on Salvage Re-Irradiation for Non-Small Cell Lung Cancer |
title_fullStr | Toxicity of Proton Therapy versus Photon Therapy on Salvage Re-Irradiation for Non-Small Cell Lung Cancer |
title_full_unstemmed | Toxicity of Proton Therapy versus Photon Therapy on Salvage Re-Irradiation for Non-Small Cell Lung Cancer |
title_short | Toxicity of Proton Therapy versus Photon Therapy on Salvage Re-Irradiation for Non-Small Cell Lung Cancer |
title_sort | toxicity of proton therapy versus photon therapy on salvage re-irradiation for non-small cell lung cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876714/ https://www.ncbi.nlm.nih.gov/pubmed/35207579 http://dx.doi.org/10.3390/life12020292 |
work_keys_str_mv | AT yangkyungmi toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer AT suhyanggun toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer AT shinhyunju toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer AT pyohongryull toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer AT moonsungho toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer AT ahnyongchan toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer AT ohdongryul toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer AT chungeunah toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer AT jokwanghyun toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer AT nohjaemyoung toxicityofprotontherapyversusphotontherapyonsalvagereirradiationfornonsmallcelllungcancer |