Crystal Structures of Botulinum Neurotoxin Subtypes A4 and A5 Cell Binding Domains in Complex with Receptor Ganglioside

Botulinum neurotoxins (BoNT) cause the potentially fatal neuroparalytic disease botulism that arises due to proteolysis of a SNARE protein. Each BoNT is comprised of three domains: a cell binding domain (H(C)), a translocation domain (H(N)), and a catalytic (Zn(2+) endopeptidase) domain (LC). The H(...

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Detalles Bibliográficos
Autores principales: Gregory, Kyle S., Mojanaga, Otsile O., Liu, Sai Man, Acharya, K. Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876736/
https://www.ncbi.nlm.nih.gov/pubmed/35202156
http://dx.doi.org/10.3390/toxins14020129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876736/
https://www.ncbi.nlm.nih.gov/pubmed/35202156
http://dx.doi.org/10.3390/toxins14020129

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