Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior of a Novel Chlorthalidone-Caffeine Cocrystal

A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which a 2:1 stoichiometric ratio was found by powder and single-crystal X-ray diffraction analysis. Cocrystal CTD-CAF showed a supramolecular organization in which CAF m...

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Detalles Bibliográficos
Autores principales: Rodríguez-Ruiz, Christian, Montes-Tolentino, Pedro, Domínguez-Chávez, Jorge Guillermo, Morales-Rojas, Hugo, Höpfl, Herbert, Herrera-Ruiz, Dea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876770/
https://www.ncbi.nlm.nih.gov/pubmed/35214066
http://dx.doi.org/10.3390/pharmaceutics14020334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876770/
https://www.ncbi.nlm.nih.gov/pubmed/35214066
http://dx.doi.org/10.3390/pharmaceutics14020334

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