Cargando…

In Silico Molecular Characterization of Human TMPRSS2 Protease Polymorphic Variants and Associated SARS-CoV-2 Susceptibility

The 2019 coronavirus disease (COVID-19) pandemic continues to challenge health care systems worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for the cause of global pandemic. Type 2 transmembrane serine protease (TMPRSS2) is important in the cell entry and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salleh, Mohd Zulkifli, Deris, Zakuan Zainy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876804/ https://www.ncbi.nlm.nih.gov/pubmed/35207518 http://dx.doi.org/10.3390/life12020231

Ejemplares similares

Structural Evaluation of the Spike Glycoprotein Variants on SARS-CoV-2 Transmission and Immune Evasion
por: Salleh, Mohd Zulkifli, et al.
Publicado: (2021)

Immunogenicity mechanism of mRNA vaccines and their limitations in promoting adaptive protection against SARS-CoV-2
por: Salleh, Mohd Zulkifli, et al.
Publicado: (2022)

Structural Insights into Substrate Binding and Antibiotic Inhibition of Enterobacterial Penicillin-Binding Protein 6
por: Salleh, Mohd Zulkifli, et al.
Publicado: (2022)

Prevalence of Multidrug-Resistant Diarrheagenic Escherichia coli in Asia: A Systematic Review and Meta-Analysis
por: Salleh, Mohd Zulkifli, et al.
Publicado: (2022)

Low Seroprevalence of SARS-CoV-2 among Healthcare Workers in Malaysia during the Third COVID-19 Wave: Prospective Study with Literature Survey on Infection Prevention and Control Measures
por: Nik Zuraina, Nik Mohd Noor, et al.
Publicado: (2022)

Prevalence of Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-Producing Shigella Species in Asia: A Systematic Review and Meta-Analysis
por: Salleh, Mohd Zulkifli, et al.
Publicado: (2022)

Missed by RTK, caught by PCR, unimagined chest Radiograph
por: Mazlan, Mohd Zulfakar, et al.
Publicado: (2021)

In-silico screening for identification of potential inhibitors against SARS-CoV-2 transmembrane serine protease 2 (TMPRSS2)
por: Barge, Sagar, et al.
Publicado: (2021)

A 9-year study of shigellosis in Northeast Malaysia: Antimicrobial susceptibility and shifting species dominance
por: Banga Singh, Kirnpal-Kaur, et al.
Publicado: (2010)

Diagnostic Accuracy of Rapid Antigen Test Kits for Detecting SARS-CoV-2: A Systematic Review and Meta-Analysis of 17,171 Suspected COVID-19 Patients
por: Khandker, Shahad Saif, et al.
Publicado: (2021)

Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease
por: Stevaert, Annelies, et al.
Publicado: (2022)

Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 (TMPRSS2) and SARS-CoV-2
por: Saih, Asmae, et al.
Publicado: (2021)

Potential Usefulness of Bacteriophages for the Treatment of Multidrug-Resistant Acinetobacter Infection
por: Raees, Fahad, et al.
Publicado: (2023)

Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester
por: Weatherbee, Bailey A. T., et al.
Publicado: (2020)

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2
por: Azouz, Nurit P., et al.
Publicado: (2020)

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2
por: Azouz, Nurit P., et al.
Publicado: (2021)

TMPRSS2: An Equally Important Protease as ACE2 in the Pathogenicity of SARS-CoV-2 Infection
por: Parmar, Malvinder S.
Publicado: (2021)

Development of Multiplex PCR Assay for Screening of T6SS-5 Gene Cluster: The Burkholderia pseudomallei Virulence Factor
por: Semail, Noreafifah, et al.
Publicado: (2022)

Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19
por: Posadas-Sánchez, Rosalinda, et al.
Publicado: (2022)

Genetic Analysis of the Coronavirus SARS-CoV-2 Host Protease TMPRSS2 in Different Populations
por: Russo, Roberta, et al.
Publicado: (2020)

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
por: Wettstein, Lukas, et al.
Publicado: (2021)

SARS-CoV-2 Targets by the pscRNA Profiling of ACE2, TMPRSS2 and Furin Proteases
por: Zhou, Lulin, et al.
Publicado: (2020)

In Vitro Anti-Leptospiral Activity of Phyllanthus amarus Extracts and Their Combinations with Antibiotics
por: Ismail, Che Ain Munirah, et al.
Publicado: (2021)

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients
por: Sacconi, Andrea, et al.
Publicado: (2020)

Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges
por: Mahmoud, Ismail Sami, et al.
Publicado: (2021)

ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients
por: Ravaioli, Sara, et al.
Publicado: (2020)

The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection
por: Qi, Jing, et al.
Publicado: (2021)

Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2
por: Vo, Thao, et al.
Publicado: (2022)

Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 infection in the lung epithelium
por: Schuler, Bryce A., et al.
Publicado: (2020)

Improving Soluble Expression of SARS-CoV-2 Spike Priming Protease TMPRSS2 with an Artificial Fusing Protein
por: Ye, Xiao, et al.
Publicado: (2023)

Prediction of the Effects of Variants and Differential Expression of Key Host Genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 Pathogenesis: An In Silico Approach
por: Hossain, Md. Shahadat, et al.
Publicado: (2021)

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir
por: Ullrich, Sven, et al.
Publicado: (2022)

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein
por: Kishimoto, Mai, et al.
Publicado: (2021)

Targeting TMPRSS2 in SARS-CoV-2 Infection
por: Baughn, Linda B., et al.
Publicado: (2020)

SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study
por: Baby, Krishnaprasad, et al.
Publicado: (2021)

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
por: Zang, Ruochen, et al.
Publicado: (2020)

Prostate adenocarcinoma and COVID‐19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS‐CoV‐2
por: Cheng, Jingliang, et al.
Publicado: (2021)

Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection
por: Maggio, Roberto, et al.
Publicado: (2020)

Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L
por: Prasad, Kartikay, et al.
Publicado: (2021)

Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2
por: Karimian, Ali, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_btrmpavmi68td115sst0tno3bj