In Silico Analysis and Synthesis of Nafamostat Derivatives and Evaluation of Their Anti-SARS-CoV-2 Activity

Inhibition of transmembrane serine protease 2 (TMPRSS2) is expected to block the spike protein-mediated fusion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nafamostat, a potent TMPRSS2 inhibitor as well as a candidate for anti-SARS-CoV-2 drug, possesses the same acyl substructure...

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Detalles Bibliográficos
Autores principales: Fujimoto, Kazuhiro J., Hobbs, Daniel C. F., Umeda, Miki, Nagata, Akihiro, Yamaguchi, Rie, Sato, Yoshitaka, Sato, Ayato, Ohmatsu, Kohsuke, Ooi, Takashi, Yanai, Takeshi, Kimura, Hiroshi, Murata, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876814/
https://www.ncbi.nlm.nih.gov/pubmed/35215982
http://dx.doi.org/10.3390/v14020389

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