Binding of the angiogenic/senescence inducer CCN1/CYR61 to integrin α(6)β(1) drives endocrine resistance in breast cancer cells

CCN1/CYR61 promotes angiogenesis, tumor growth and chemoresistance by binding to its integrin receptor α(v)β(3) in endothelial and breast cancer (BC) cells. CCN1 controls also tissue regeneration by engaging its integrin receptor α(6)β(1) to induce fibroblast senescence. Here, we explored if the abi...

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Detalles Bibliográficos
Autores principales: Espinoza, Ingrid, Yang, Lin, Steen, Travis Vander, Vellon, Luciano, Cuyàs, Elisabet, Verdura, Sara, Lau, Lester, Menendez, Javier A., Lupu, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876916/
https://www.ncbi.nlm.nih.gov/pubmed/35148282
http://dx.doi.org/10.18632/aging.203882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876916/
https://www.ncbi.nlm.nih.gov/pubmed/35148282
http://dx.doi.org/10.18632/aging.203882

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